天津医药

天津医药 ›› 2015, Vol. 43 ›› Issue (10): 1205-1208.doi: 10.11958/j.issn.0253-9896.2015.10.032

• 综述 • 上一篇    下一篇

蛋白质二硫键异构酶在心血管疾病中作用机制的研究进展

  

  1. 1三峡大学人民医院 （邮编 443002）； 2宜昌市第一人民医院
  • 收稿日期:2015-06-15 修回日期:2015-07-19 出版日期:2015-10-15 发布日期:2015-10-22

Protein disulfide isomerase’ s role in cardiovascular disease

  1. 1 People's Hospital of Three Gorges University, Yichang 443002, China； 2 The First People's Hospital of Yichang
  • Received:2015-06-15 Revised:2015-07-19 Published:2015-10-15 Online:2015-10-22

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摘要： 摘要： 蛋白质二硫键异构酶是一种主要存在于内质网中的巯基-二硫键氧化还原酶。已经证实其具有催化二硫
键形成及重排、 调节蛋白质的折叠等多种生物学功能， 现发现该蛋白也可作为一个潜在的心血管疾病生物学标志
物， 在急性心肌梗死中可以减少梗死面积和凋亡心肌细胞数目； 在糖尿病心肌病中， 能降低心肌易损性； 在高血压和
血栓形成过程中也担任着一个重要的角色。因此， 本文主要针对蛋白质二硫键异构酶在心血管疾病发生发展中的机制研究进展予以综述。

关键词: 蛋白质二硫化物异构酶, 心肌梗死, 糖尿病并发症, 心肌疾病, 高血压, 血栓形成, 综述

Abstract: Abstract: Protein disulfide isomerase (PDI) is one of thiol-disulfide oxidoreductases that mainly located in the endo⁃
plasmic reticulum (ER). It is generally known that PDI caralyzes the formation， rearrangement， breakage of disulfide bonds，
and this enzyme is effective in regulation of protein folding. Now it is also known as a biomarker of cardiovascular disease.
Protein disulfide isomerase can reduce infarct size and myocardial apoptosis in acute myocardial infarction (AMI). PDI can
also improve changes of cardiac vulnerability in diabetic cardiomyopathy (DCM). Further more, it is also shown that PDI play
an important role in hypertension and thrombosis. Therefore, this paper review the effects of protein disulfide isomerase in
cardiovascular diseases.

Key words: protein disulfide- isomerase, myocardial infarction, diabetes complications, cardiomyopathies, hyperten?
sion, thrombosis, review