天津医药

天津医药 ›› 2015, Vol. 43 ›› Issue (11): 1322-1325.doi: 10.11958/j.issn.0253-9896.2015.11.027

• 应用研究 • 上一篇    下一篇

慢性鼻-鼻窦炎综合治疗的临床分析

邱新峰 1， 何京川 2， 翟翔 2#br#   

  1. 1天津市第五中心医院耳鼻喉科 （邮编300450）； 2天津市环湖医院耳鼻咽喉头颈外科
  • 收稿日期:2015-04-28 修回日期:2015-07-08 出版日期:2015-11-15 发布日期:2015-11-15
  • 通讯作者: 邱新峰 E-mail:qxfaq@163.com
  • 作者简介:邱新峰 （1977）， 男， 学士， 主要从事鼻部相关疾病的临床诊治及基础研究

Analysis of efficacy of comprehensive treatment in patients with chronic sinusitises

QIU Xinfeng1, HE Jingchuan2, ZHAI Xiang2#br#   

  1. 1 Department of Otolaryngology Head and Neck Surgery, Tianjin Fifth Central Hospital, Tianjin 300450, China; 2 Department of Otolaryngology Head and Neck Surgery, Tianjin Huanhu Hospital
  • Received:2015-04-28 Revised:2015-07-08 Published:2015-11-15 Online:2015-11-15

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摘要： 目的 评估以中性粒细胞浸润为主和以嗜酸性粒细胞浸润为主的两种病理学特征的慢性鼻-鼻窦炎综合治疗的临床效果。方法 选取经住院手术治疗后症状未得到改善、 术后 3 个月视觉模拟量表 （VAS） 主观症状评分＞6分的慢性鼻窦炎患者 256 例。根据细胞浸润类型给予不同的综合治疗方案， 观察治疗后患者 VAS 主观症状评分、Lund-Kennedy 内镜评分及鼻组织病理学检查的改善情况。结果 综合治疗后， 以嗜酸性粒细胞浸润为主的患者主观症状及鼻内镜检查有明显改善， 鼻组织嗜酸性粒细胞的数目未见明显减少； 以中性粒细胞浸润为主的患者主观症状及鼻内镜检查均得到明显改善， 中性粒细胞数降低。结论 根据不同的免疫病理学特征， 慢性鼻窦炎的患者要给予不同的治疗方案， 以中性粒细胞浸润为主的疗效明显。

关键词: 鼻炎, 鼻窦炎, 慢性病, 中性白细胞浸润, 嗜酸细胞, 外科手术, 综合疗法

Abstract: Objective To assess clinical efficacy of comprehensive treatment on chronic sinusitises (CRS) with neutrophils infiltration and eosinophilic infiltration as pathological features. Methods A total of 256 CRS patients whose symptoms were not been improved after surgery (visual analog scale＞6， 3 months after surgery) were included in this study. Different comprehensive treatments were given to the patients according to the different types of cell infiltration. The visual analog scale (VAS), Lund-Kennedy and nasal histopathological examination were observed after treatment in patients. Results After different comprehensive treatments, the VAS and Lund-Kennedy were improved in patients with eosinophils infiltration, but the number of eosinophils was not reduced. The VAS, Lund-Kennedy and the number of neutrophils were significantly improved in patients with mainly neutrophils infiltration. Conclusion According to different immune pathological characteristics, patients of CRS should be given different comprehensive treatments. There is a obvious efficacy for patients with neutrophil infiltration.

Key words: rhinitis, sinusitis,  chronic disease,  neutrophil infiltration, eosinophils, surgical procedures, operative, combined modality therapy