天津医药

天津医药 ›› 2015, Vol. 43 ›› Issue (12): 1464-1466.doi: 10.11958/j.issn.0253-9896.2015.12.032

• 综述 • 上一篇    下一篇

Prdx1 与肿瘤

高军1,朱虹1,高国兰2△   

  1. 1江西省人民医院妇科（邮编330006）；2中国医科大学航空总医院妇科
  • 收稿日期:2015-06-23 修回日期:2015-08-19 出版日期:2015-12-15 发布日期:2015-12-11
  • 通讯作者: △审校者和通讯作者E-mail：gaojun19777@163.com E-mail:gaojun19777@163.com
  • 作者简介:高军（1977），男，博士，在站博士后，副主任医师，主要从事妇科恶性肿瘤的基础与临床研究
  • 基金资助:
    国家自然科学基金资助项目(30860301）；江西省科技支撑计划项目（20123BBG70231）

The relationship between Prdx1 and carcinoma

GAO Jun1, ZHU Hong1, GAO Guolan2△   

  1. 1 Department Gynecology, Jiangxi Provincial People′s Hospital, Nanchang 330006, China；2 Department Gynecology,
    Aviation General Hospital
  • Received:2015-06-23 Revised:2015-08-19 Published:2015-12-15 Online:2015-12-11
  • Contact: △Reviser and Corresponding Author E-mail:gaojun19777@163.com E-mail:gaojun19777@163.com

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摘要： Prdx1（peroxiredoxin 1）属于过氧化物氧化还原酶蛋白（peroxiredoxin，Prdx）家族成员，是一类在对抗活性氧簇（ROS）、抗氧化过程中发挥关键作用的蛋白质，在多种肿瘤组织中高表达，其表达与肿瘤细胞增殖、分化、转移、复发及放化疗的敏感性密切相关。本文就Prdx1 的结构、在肿瘤中的生物学功能及其信号调控机制等进行综述，为寻找新的肿瘤生物治疗靶点提供依据。

关键词: Prdx1, 过氧化物酶, 肿瘤

Abstract: Peroxiredoxin 1（Prdx1）belongs to peroxide oxidoreductase protein（peroxiredoxin, Prdx）family，which is over-expressed in multiple cancers and it play an important role in antagonizing reactive oxygen species (ROS) therefore as works as anti-oxidations. Its expression is closely related with tumor proliferation, differentiation and metastasis as well as with sensibility to radiotherapy and chemotherapy. Its structure and biological function in tumors and regulation mechanism were reviewed in this paper. It can provide evidence to screen new therapeutic targets in the treatment of tumors.

Key words: Prdx1, peroxidase, neoplasms