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杨光华,白铁男,胡海龙,韩瑞发,徐健
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杨光华,白铁男,胡海龙,韩瑞发,徐健. PTEN和p38MAPK在前列腺良恶性病变中的表达及意义[J]. .
摘要： 目的：探讨PTEN蛋白及丝裂素活化蛋白激酶p38（p38MAPK，p38）在前列腺良恶性病变组织中的表达差异及其临床意义。方法：应用免疫组织化学SABC法检测20例良性前列腺增生（BPH）组织、20例前列腺上皮内瘤（PIN）组织及46例前列腺癌（PC）组织中的PTEN和p38的表达。结果：PTEN在BPH、PIN和PC组织中表达活性呈递减趋势，三组之间两两比较，均有显著性差异(P 关键词: PTEN, P38MAPK, 前列腺癌, 良性前列腺增生, 前列腺上皮内瘤 Abstract: Objective: To study the different expression and clinical significance of PTEN and p38MAPK in benign and malignant prostatic lesions. Methods: SABC immunohistochemical analysis was used to determine the expression levels of PTEN and p38 in 20 cases of benign prostatic hyperplasia(BPH),20 cases of prostatic intraepithelial neoplasia(PIN) and 46 cases of prostatic carcinoma (PC). Results: Expression of PTEN was the highest in BPH and significantly higher in PIN compared to PC (P<0.01). Expression of p38 was the highest in PC and significantly higher in PIN compared to BPH(P<0.05).PTEN protein expression in prostatic carcinoma was negatively correlated with tumor stage, and histological grade(r=-0.352,-0.653,P<0.05)；while p38 expression was positively correlated with the above features(r=0.298,0.596,P<0.05).There was a negative correlation between PTEN and p38 expression(r=-0.602,P<0.01)．Conclusions: Low PTEN protein expression and elevated activation of p38 are involved in the malignant transformation of prostatic epithelium and may play a great role in the genesis and development of prostatic tumor. Key words: PTEN, p38MAPK, prostatic carcinoma, benign prostatic hyperplasia, prostatic intraepithelial neoplasia 使用本文 / 推荐 导出引用管理器 EndNote|Ris|BibTeX 链接本文: https://www.tjyybjb.ac.cn/CN/ https://www.tjyybjb.ac.cn/CN/Y2010/V38/I12/1035
关键词: PTEN, P38MAPK, 前列腺癌, 良性前列腺增生, 前列腺上皮内瘤
Abstract: Objective: To study the different expression and clinical significance of PTEN and p38MAPK in benign and malignant prostatic lesions. Methods: SABC immunohistochemical analysis was used to determine the expression levels of PTEN and p38 in 20 cases of benign prostatic hyperplasia(BPH),20 cases of prostatic intraepithelial neoplasia(PIN) and 46 cases of prostatic carcinoma (PC). Results: Expression of PTEN was the highest in BPH and significantly higher in PIN compared to PC (P<0.01). Expression of p38 was the highest in PC and significantly higher in PIN compared to BPH(P<0.05).PTEN protein expression in prostatic carcinoma was negatively correlated with tumor stage, and histological grade(r=-0.352,-0.653,P<0.05)；while p38 expression was positively correlated with the above features(r=0.298,0.596,P<0.05).There was a negative correlation between PTEN and p38 expression(r=-0.602,P<0.01)．Conclusions: Low PTEN protein expression and elevated activation of p38 are involved in the malignant transformation of prostatic epithelium and may play a great role in the genesis and development of prostatic tumor.
Key words: PTEN, p38MAPK, prostatic carcinoma, benign prostatic hyperplasia, prostatic intraepithelial neoplasia
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