天津医药

• 论著 • 上一篇    下一篇

老年2型糖尿病血清C反应蛋白与血尿酸关系探讨

侯方1,曹凤林2,范振迁3,陈雨3,郑少雄3   

  1. 1. 天津市塘沽区新医医院
    2. 医大二院血液内分泌科
    3. 天津医科大学第二医院
  • 收稿日期:2010-07-30 修回日期:2010-10-25 出版日期:2011-02-15 发布日期:2011-02-15
  • 通讯作者: 侯方

The relationships between serum C-reactive protein (CRP) and serum uric acid (SUA) levels in elderly patients with type 2 diabetes

  • Received:2010-07-30 Revised:2010-10-25 Published:2011-02-15 Online:2011-02-15
  • Contact: fang HOU

PDF (PC)

2224

摘要： 目的 探讨老年2型糖尿病，糖尿病伴高血压患者和年龄相当的正常人血清C反应蛋白 (C-RP)、血尿酸（SUA）水平之间的关系。方法 受试者分为三组，55例单纯2型糖尿病（DM组），61例2型糖尿病合并高血压者（DMG组）和54例健康的60岁以上老年人（正常对照，NC组），观察指标除体重指数（BMI）、腰围(WC)、收缩压(SBP)、舒张压(DBP)外，还测定了血清C-RP、SUA、空腹血糖（FPG）、外周血白细胞（WBC）、甘油三酯(TG)、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）等，并比较了血清C-RP、SUA与其他相关指标的关系。 结果 与NC组相比， DMG组、DM组的BMI、WC均显著增高（P<0．01），WBC、TC亦增高（P<0.05）；DMG组、DM组的C-RP、SUA、TG、LDL-C、FPG均显著增高（P<0.01）；与DM组相比，DMG组C-RP、SUA、FPG增高更明显（P<0．01）, TC、LDL-C亦增高（P<0.05）。血清C-RP、SUA与TG、TC、LDL-C、FPG、 BMI、WC、SBP、DBP呈正相关（P<0．01），亦与WBC呈正相关（P<0.05）。结论 伴有高血压的老年2型糖尿病患者CRP和SUA高于单纯老年2型糖尿病患者，后者高于正常对照组，三组之间比较，CRP和SUA且呈正相关关系(r=0.335,P<0.01)。

关键词: 2型糖尿病, 高血压, C反应蛋白, 血尿酸, 血脂

Abstract: Objectives：To explore the relationships between C-reactive protein (C-RP) and serum uric acid (SUA) levels in elderly patients with and without type 2 diabetes. Methods：All the subjects, more than 60 years old, were divided into three groups, 55 diabetic patients with normal blood pressure (DM group) , 61 diabetic patients with hypertension（DMG group）, and 54 subjects without diabetes and hypertension as control(NC group) . The serum C-RP、SUA、FPG、WBC、TG、TC、HDL-C、LDL-C were assayed, and the BMI、WC、SBP、DBP were determined . Results Levels of C-RP、SUA、TG、LDL-C、FPG 、BMI、WC、SBP、DBP in the DMG and DM group were significantly higher than that in NC group（P<0.01, respectively）, and WBC and TC levels in DMG and DM group were significantly higher than the NC group（P<0.05, respectively）; levels of C-RP、SUA and FPG in DMG group were significantly higher than those in DM group（P<0．01）; TC、LDL-C in DMG group were significantly higher than those in DM group（P<0.05）. Conclusions ：In elderly type 2 diabetic hypertension group, the level of C-reactive protein and serum uric acid increased significantly, which was higher than the control group. Among the three groups, there are positive correlation between CRP and SUA (r = 0.335, P < 0.01). Key word: Type 2 diabetes, Hypertension, C-reactive protein (CRP), Serum uric acid (SUA), Serum lipids

Key words: Type 2 diabetes, Hypertension, C-reactive protein (CRP), Serum uric acid (SUA), Serum lipids