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初诊2型糖尿病胰岛素治疗与胰岛功能的临床观察

周成梅   

  1. 临沂市中医医院
  • 收稿日期:2010-07-08 修回日期:2010-09-09 出版日期:2011-03-15 发布日期:2011-03-15
  • 通讯作者: 周成梅

Clinical observation of βcell function and insulin treatment on newly diagnosed type 2 diabetics

ZHOU cheng mei   

  • Received:2010-07-08 Revised:2010-09-09 Published:2011-03-15 Online:2011-03-15
  • Contact: ZHOU cheng mei

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摘要： 目的 探讨初诊2型糖尿病患者单纯口服药物与胰岛素治疗对胰岛功能的影响。方法 选取初诊2型糖尿病患者120例，空腹血糖均≥11.1mmol/ L,随机分为胰岛素治疗组（试验组）、口服药物治疗组（对照组）两组，血糖达标为在5～14天内末梢空腹血糖≤6.0 mmol/L ,餐后2小时血糖≤8.0mmol/L治疗2～6个月后，测定空腹、餐后2小时C肽及其对应的血糖，并对两组结果进行比较。 结果 试验组在2～6月后60例均停药，对照组仅4例出现停药情况。且试验组检查胰岛功能恢复情况较对照组好。结论 早期胰岛素治疗能降低高糖毒性，更好地改善胰岛功能，且越快控制好血糖越容易出现停药。

关键词: 糖尿病, 2型, 胰岛素, 治疗, 胰岛β细胞功能

Abstract: Objective To investigate the β cell function in newly diagnosed type 2 diabetes treated with oral hypoglycemic agents(OHA) and insulin treatment. Method 120 patients with newly diagnosed type 2 diabetes were randomly divided into two groups , fasting blood glucose were more than 11.0mmol/L ,treated with OHA and insulin.The targets for glycemic control were fasting blood glucose less than 6.0mmol/L ,and two hours postprandial blood glucose less than 8.0 mmol/L ,which were achieved in 5～14 days,and had been lasted for 2～6 months. Before and after intensive therapy peptide C and blood glucose was performed to calculate between two groups .Results 60 cases of insulin group stopped medication after 6 months;while only 4 cases of OHA group stopped. The results displayed that insulin treatment may improve the function of beta-cell than OHA group. Conclusions Insulin treatment at early stages of 2 type diadetic patients could remove glucose toxicity and excellently improve β cell function .And the glucose were targeted more quickly , medication were stopped more early .

Key words: Diabetes, type 2, Insulin, treatment, Islet βcell function