天津医药

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替米沙坦对高脂喂养大鼠血清NO及iNOS的影响

葛进1,郑喜兰2,雒瑢2,田凤石2   

  1. 1. 天津公安医院
    2. 公安医院
  • 收稿日期:2010-11-11 修回日期:2011-03-03 出版日期:2011-06-15 发布日期:2011-06-15
  • 通讯作者: 葛进

  • Received:2010-11-11 Revised:2011-03-03 Published:2011-06-15 Online:2011-06-15

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摘要： 【摘要】目的 观察替米沙坦对高脂喂养自发性2型糖尿病OLETF大鼠血清一氧化氮（NO）及诱导型一氧化氮合酶（iNOS）的影响。方法 4周龄自发性2型糖尿病OLETF大鼠20只，8周龄开始高脂喂养。22周龄根据OGTT 2 h血糖和体重随机分为高脂组（O组），替米沙坦组（L组）。LETO大鼠12只，为空白对照组（NC组）。48周龄时检测血清中NO、一氧化氮合酶（NOS）、iNOS、单核细胞趋化蛋白1（MCP-1）及游离脂肪酸（FFA）变化。结果 ⑴ L组NO显著降低于O组（P=0.011），iNOS在L组和O组均有所上升，但L组与O组比较无差异，与NC组比较存在显著性差异（P=0.024）。⑵ NO与MCP-1和FFA均呈正相关（P<0.05）。结论 替米沙坦可能通过抗炎作用调节iNOS合成使高脂喂养大鼠血清NO水平降低。 【关键词】OLETF大鼠；替米沙坦；一氧化氮；诱导型一氧化氮合酶

关键词: OLETF大鼠, 替米沙坦, 一氧化氮, 诱导型一氧化氮合酶

Abstract: 【Abstract】 Objective To investigate the effect of telmisartan on the nitric oxide(NO) and inducible NO synthase (iNOS)of OLETF rats fed with high-fat diet. Methods According to OGTT 2 h and body weight, twenty OLETF rats were randomly divided into the telmisartan group (group L), and the high-fat diet group (group O). Twelve LETO rats fed with normal diet served as normal control group (group NC). At forty-eight weeks, NO, NOS, iNOS, MCP-1and FFA in blood serum was measured. Results ⑴NO in group L was lower than that in group O (P=0.011). iNOS in group L and group O were higher than that in group NC, but group L and group O no statistical significance, compared with group NC, iNOS in group L were marker higher (P=0.024).⑵ The NO was significantly correlated with MCP-1 and FFA（P<0.05）. Conclusion telmisartan accommodate iNOS creation by controlling infection reaction, it caused decline of the NO of OLETF rats fed with high-fat diet. 【Key word】OLETF rat; telmisartan; NO; iNOS

Key words: Key wordOLETF rat, telmisartan, NO, iNOS