天津医药

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小剂量芬太尼对老龄女性喉罩置入丙泊酚半数有效浓度的影响

杨少勇,张广华   

  1. 天津医科大学附属肿瘤医院
  • 收稿日期:2011-02-12 修回日期:2011-02-16 出版日期:2011-07-15 发布日期:2011-07-15
  • 通讯作者: 杨少勇

The effect of low dose fentanyl on EC50 of propofol for laryngeal mask insertion

  • Received:2011-02-12 Revised:2011-02-16 Published:2011-07-15 Online:2011-07-15

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摘要： 摘要：目的 喉罩适用于老年人短小手术麻醉，本研究为了探讨合理的诱导药物配伍，测定小剂量芬太尼（50μg）对老龄女性喉罩置入丙泊酚半数有效浓度的影响。方法：择期行全麻下乳腺手术手术病人84例，根据年龄分为两组，老年组年龄≥65岁，普通组年龄<65岁，每组再随机分为芬太尼50μg复合丙泊酚组及单纯丙泊酚组， 应用Dixon贯续法预设丙泊酚靶控输注浓度，并计算各组EC50值。结果：普通组EC50为4.03土0.21μg.ml-1，普通组复合芬太尼组为3.07土0.23μg.ml-1，老年组3.76土0.42μg.ml-1，老年复合芬太尼组为2.35土0.22μg.ml-1。各组循环抑制发生率相似，无知晓事件，但老年复合芬太尼组呼吸抑制发生率增加。结论：小剂量芬太尼50μg可有效降低喉罩插入所需丙泊酚靶控输注的半数有效浓度，这种协同作用对于老年人更明显且不增加循环抑制的发生率。 关键词：芬太尼，老年，半数有效浓度，喉罩，丙泊酚

关键词: 芬太尼, 老年, 半数有效浓度, 丙泊酚, 喉罩

Abstract: Abstract Objective:To investgat whether supplemental fentanyl 50μg decreased the effective concentration for 50% of the attempts to secure laryngeal mask insertion of propofol using a target controlled infusion technology. Method: eighty-four elective patients were divided into 2 groups by ages and then randomly assigned to four groups (n = 21 for each group) and given saline (control) or fentanyl 50μg. Propofol target concentration was determined and EC50 was calculated by a modification of Dixon's up-and-down method. Complication occurrence of circulation and respiration system and awareness were record during the insertion. Results: The EC50 of normal group without tentanyl was 4.03土0.21μg.ml-1，normal plus fentanyl 3.07土0.23μg.ml-1，and in geriatric group3.76土0.42μg.ml-1，geriatric plus fentanyl2.35土0.22μg.ml-1。The accurrence of circulation depression were comparable in four group,and no awareness happened in all patients, but in group geriatric plus fentanyl the accurence of respiration depression is more than the other groups. Conclusion: A fentanyl dose of 50μg is suffcient to decrease EC50 of propofol TCI to secure laryngeal mask insertion in normal and geriatric patients with minimum cardiovescular depression. Key words: fentanyl, geriatric, median effective concentration , propofol, laryngeal mask

Key words: fentanyl, geriatric, median effective concentration, propofol, laryngeal mask