天津医药

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补充叶酸和复合维生素B降低脑卒中患者复发的研究?

张克明   

  1. 天津中医药大学第一附属医院
  • 收稿日期:2011-06-20 修回日期:2011-10-27 出版日期:2012-05-15 发布日期:2012-05-15
  • 通讯作者: 张克明

Study on the Role of Folic Acid and Compound Vitamin B in Reducing Stroke Recurrence

ZhangKeMing   

  • Received:2011-06-20 Revised:2011-10-27 Published:2012-05-15 Online:2012-05-15
  • Contact: ZhangKeMing

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摘要： 摘要 目的：探讨叶酸和复合维生素B（VitB）对血浆同型半胱氨酸（Hcy）与脑卒中的作用。方法：采用酶联免疫法检测134例脑卒中患者的血浆Hcy水平，随机分为叶酸和复合VitB干预组和常规治疗组各67例，观察干预效果。 结果：补充叶酸和复合VitB后，干预组血浆Hcy下降水平明显低于对照组，差别有统计学意义（P=0.029）；干预组脑卒中患者复发率低于常规治疗组（P=0.02）。结论：血浆Hcy升高是脑卒中患者的重要危险因素，补充叶酸和复合VitB可降低血浆Hcy水平，对预防和治疗脑卒中具有重要意义。

关键词: 叶酸, 复合维生素B, 脑卒中, 同型半胱氨酸

Abstract: Abstract Objective: To study the effect of folic acid and compound vitamin B on plasma homocysteine level and stroke. Methods: Enzymatic cycling assay was used to measure the plasma homocysteine levels in 134 patients with stroke. By screening, patients were randomly sub-divided into folic acid and compound vitamin B intervention group (n=67) and conventional treatment (n=67) group to observe the effect of intervention. Results: The plasma homocysteine level of intervention group reduced significantly (P=0.029). Recurrence rate of intervention group was significantly lower than that of the conventional treatment group (P=0.02). Conclusion: Increasing level of plasma homocysteine is a significant risk factor of stroke. Adding folic acid and compoun vitamin B can reduce the level of plasma homocysteine and play a key role in prevention and treatment of stroke.

Key words: folic acid, compound vitamin B, stroke, homocysteine