天津医药 ›› 2017, Vol. 45 ›› Issue (12): 1316-1319.doi: 10.11958/20170771

• 临床研究 • 上一篇    下一篇

2 型糖尿病患者血小板反应蛋白-1 与 颈动脉粥样硬化的关系

边志颖, 胡艳云, 王君, 孙倩, 郄海静, 赵新翠, 肖艳新, 尹超   

  1. 基金项目: 河北省 2016 年度医学科学研究重点课题计划 (20160006) 作者单位: 保定市第一中心医院内分泌三科 (邮编 071000) 作者简介: 边志颖 (1985), 女, 硕士, 主治医师, 主要从事糖尿病及相关并发症研究
  • 收稿日期:2017-07-03 修回日期:2017-11-12 出版日期:2017-12-15 发布日期:2017-12-15
  • 通讯作者: 边志颖 E-mail:bianzhiying1985@163.com
  • 基金资助:
    河北省2016年度医学科学研究重点课题计划

The relationship between the thrombospondin-1 and the carotid atherosclerosis in patients with type 2 diabetic

BIAN Zhi-ying, HU Yan-yun, WANG Jun, SUN Qian, QIE Hai-jing, ZHAO Xin-cui, XIAO Yan-xin, YIN Chao   

  1. Department of Endocrinology, the First Central Hospital of Baoding, Baoding 071000, China
  • Received:2017-07-03 Revised:2017-11-12 Published:2017-12-15 Online:2017-12-15

摘要: 目的 探讨 2 型糖尿病患者血清血小板反应蛋白-1(TSP-1)与颈动脉粥样硬化及其相关指标之间的关 系。方法 选取 2 型糖尿病患者 101 例, 根据是否合并颈动脉粥样硬化分为单纯 2 型糖尿病组 (A 组, n=52)、 2 型糖 尿病合并颈动脉粥样硬化组(B 组, n=49); 另选 50 例体检健康者为正常对照组(C 组, n=50)。检测各研究对象的 TSP-1、 空腹血糖(FPG)、 空腹胰岛素(FINS)、 糖化血红蛋白(HbA1c)、 三酰甘油(TG)、 总胆固醇(TC)、 低密度脂蛋白 胆固醇 (LDL-C)、 高密度脂蛋白胆固醇 (HDL-C)、 纤维蛋白原 (Fib)、 同型半胱氨酸 (Hcy) 等指标在 3 组间的差异, 分 析 TSP-1 与其他相关指标的相关性。结果 3 组舒张压(DBP)、 体质量指数(BMI)差异无统计学意义(P>0.05)。B 组收缩压(SBP)高于 A 组与 C 组(P<0.01), 但 A 组与 C 组之间比较差异无统计学意义(P>0.05)。3 组间 TC、 TG、 HDL-C 差异无统计学意义(P>0.05)。、 B 组、 A 组及 C 组间 TSP-1、 Hcy 依次增高, 差异均有统计学意义(P<0.05)。 3 组间 FPG、 HbA1c、 Fib、 FINS 及 LDL-C 差异有统计学意义(P<0.05)。TSP-1 与 FPG、 FINS、 HbA1c、 Fib、 Hcy 呈正 相关 (r 值分别为 0.585、 0.341、 0.701、 0.409、 0.351, 均 P<0.05)。线性回归分析显示, TSP-1 受 FINS、 HbA1c 及 Fib 的 影响, 其中 HbA1c 影响较大。结论 TSP-1 与糖尿病大血管病变发生、 发展有关, 对早期发现、 早期治疗糖尿病大血 管病变、 延缓疾病进展具有很好的临床价值。

关键词: 糖尿病, 2 型, 血小板反应蛋白-1, 颈动脉粥样硬化, 同型半胱氨酸

Abstract: Objective To investigate the relationship between the thrombospondin-1 (TSP-1) and carotid atherosclerosis and its related indicators in patients with type 2 diabetes mellitus (T2DM). Methods A total of 101 T2DM patients were divided into T2DM group (A group, n = 52) and T2DM with carotid artery atherosclerosis group (B group, n = 49) according to whether complicated with carotid artery atherosclerosis, and 50 normal healthy persons were used as the normal group (C group , n=50). The TSP-1 and other clinical indicators were detected including fasting blood sugar (FPG), fasting insulin (FINS), glycosylated hemoglobin (HbA1c), triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), fibrinogen (Fib) and homocysteine (homocysteine). The differences between TSP-1 and other related indicators were analyzed. Results There were no significant differences in diastolic blood pressure (DBP) and body mass index (BMI) between the 3 groups (P>0.05). The level of systolic blood pressure (SBP) was significantly higher in group B than that of group A and group C (P<0.01), but there was no significant difference between group A and group C (P>0.05). There were no significant differences in TC, TG and HDL-C between three groups (P>0.05). The values of TSP-1 and Hcy were increased sequentially in group B, group A and group C (P < 0.05). There were significant differences in FPG, HbA1c, Fib, FINS and LDL-C between three groups (P<0.05). TSP-1 was positively correlated with FPG, FINS, HbA1c, Fib and Hcy (r= 0.585, 0.341, 0.701, 0.409 and 0.351, P < 0.05). Linear regression analysis showed that TSP-1 was affected by FINS, HbA1c and Fib, and HbA1c was more important. Conclusion TSP-1 is associated with the occurrence and development of diabetic macrovascular complications. It has good clinical value for early detection, early treatment and delaying the progress of diabetic macrovascular diseases.

Key words: diabetes mellitus, type 2, thrombospondin-1, carotid artery atherosclerosis, homocysteine