天津医药

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慢性心力衰竭患者血清胱抑素C与心功能的关系

周月涛,卢志先   

  1. 葛洲坝中心医院三峡大学第三临床医学院
  • 收稿日期:2011-07-28 修回日期:2011-11-25 出版日期:2012-08-15 发布日期:2012-08-15
  • 通讯作者: 周月涛

The Relationship between Serum Cystatin C and Cardiac Function in Patients with Chronic Heart Failure

  • Received:2011-07-28 Revised:2011-11-25 Published:2012-08-15 Online:2012-08-15

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摘要： 摘要 目的：探讨慢性心力衰竭(CHF)患者血清胱抑素C (CysC)水平与心功能的关系。方法：选取住院超过2周的CHF患者193例，应用超声心动图测量其治疗前及治疗2周后的左心室舒张末期内径(LVEDD) 、左心室收缩末期内径(LVESD) 及左心室射血分数(LVEF)，并检测血清胱抑素C水平及6分钟步行试验(6-MWT)。比较治疗前后各检测值的变化及关系。结果：CHF患者治疗后血清CysC水平显著下降(P <0.05)且与LVEDD、LVESD、LVEF及6-MWT呈负相关性(P <0.05)。结论：CysC与CHF的发生发展有密切关系，可作为反映CHF患者心功能的重要指标。

关键词: 心力衰竭, 慢性, 胱抑素C, 超声心动描记术, 多普勒, 心室功能, 左

Abstract: Abstract Objective：To investigate the relationship between serum Cystatin C (CysC) and cardiac function in patients with chronic heart failure(CHF). Methods：193 patients to be hospitalized over 2 weeks with CHF were colleced . Left ventricular end-diastolic diameter (LVEDD),left ventricular end-systolic diameter(LVESD) and left ventricular ejection fraction(LVEF)were measured by echocardiography before and 2 weeks after therapy.The level of serum CysC and 6-minute walk test(6-MWT) were determined too.Their results and relationship were compared. Results：The level of serum CysC decreased significantly(P <0.05) after therapy.The relationship between serum CysC and LVEDD、LVESD、LVEF、6-MWT was negative correlation (P <0.05).Conclusions：There were close relationship between CysC and CHF. CysC was a potential biomarker in reflect the cardiac function of patients with CHF.

Key words: heart failure, chronic Cystatin C echocardiography, Dopplerventricular function, left