关键词: 肺疾病, 慢性阻塞性, 氧化性应激, 丙二醛, 超氧化物歧化酶, 谷胱甘肽过氧化酶, C反应蛋白质, 白细胞介素6

Abstract:

[Abstract] Objective  To study the effects of oxidant/antioxidant imbalance on inflammation reaction during acute exacerbation of chronic obstructive pulmonary disease(COPD).Methods  Fifty patients with acute exacerbation of COPD were collected, including 30 patients with moderate COPD and 20 patients with severe COPD. Fifty health controls，matched to the cases with gender and age，were included in the study. The serum levels of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), total-antioxidant capability (T-AOC), C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were measured and compared between three groups. Results  The serum levels of SOD, GSH-Px and T-AOC were significantly lower in moderate and severe COPD groups than those of control group, but the serum levels of MDA, CRP, IL-6 and TNF-α were significantly higher than those of control group( P﹤0.001). The serum levels of SOD, GSH-Px and T-AOC were significantly higher in moderate COPD group than those of severe COPD group, but the serum levels of MDA, CRP, IL-6 and TNF-α were significantly lower in moderate COPD group than those of severe COPD group (P﹤0.001). The serum levels of MDA were positively correlated with serum levels of CRP, IL-6 and TNF-α. The serum levels of T-AOC, SOD and GSH-Px were negatively correlated with serum levels of CRP, IL-6 and TNF-α (P < 0.01). Conclusion  The imbalance of oxidant/antioxidant can promote inflammation, which accelerates the onset and progress of inflammatory reaction during acute exacerbation of COPD.

Key words: pulmonary disease, chronic obstructiveoxidative stress malondialdehydesuperoxide dismutase glutathione peroxidaseC-reactive proteininterleukin-6 tumor necrosis factor-alpha, 白细胞介素6