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氧化/抗氧化失衡与COPD急性加重期炎症反应的关系*

王艳蕾   

  1. 河北联合大学
  • 收稿日期:2012-06-06 修回日期:2012-10-19 出版日期:2013-04-15 发布日期:2013-04-15
  • 通讯作者: 王艳蕾

Relationship between Oxidant/antioxidant Imbalance and Inflammation Reaction during Acute Exacerbation of Chronic Obstructive Pulmonary Disease

WANG Yan-Lei   

  1. Hebei United University, Tangshan 063000, China
  • Received:2012-06-06 Revised:2012-10-19 Published:2013-04-15 Online:2013-04-15
  • Contact: WANG Yan-Lei

摘要:

【摘要】目的 探讨氧化/抗氧化失衡在慢性阻塞性肺疾病(COPD)急性加重期炎症反应中的作用。方法  COPD急性加重期患者50例,依疾病严重程度分为中度组30例,重度组20例。选取同期健康体检者(对照组)50例。测量各组血清丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、总抗氧化能力(T-AOC)水平以及血清C-反应蛋白(CRP)、白细胞介素(IL)-6、肿瘤坏死因子(TNF)-α含量,并进行相关分析。结果 中度和重度组血清SOD、GSH-Px、T-AOC均低于对照组,而血清MDA、CRP、IL-6、TNF-α含量高于对照组(P﹤0.001);中度组血清SOD、GSH-Px、T-AOC均高于重度组,而血清MDA、CRP、IL-6、TNF-α含量低于重度组(P﹤0.001);患者血清MDA 与CRP、IL-6、TNF-α呈正相关,而血清T-AOC、SOD、GSH-Px分别与CRP、IL-6、TNF-α呈负相关(P﹤0.01)。结论 氧化/抗氧化失衡可能通过促进炎症细胞释放炎性细胞因子,加速COPD急性加重期炎症反应的发生发展。

关键词: 肺疾病, 慢性阻塞性, 氧化性应激, 丙二醛, 超氧化物歧化酶, 谷胱甘肽过氧化酶, C反应蛋白质, 白细胞介素6

Abstract:

[Abstract] Objective  To study the effects of oxidant/antioxidant imbalance on inflammation reaction during acute exacerbation of chronic obstructive pulmonary disease(COPD).Methods  Fifty patients with acute exacerbation of COPD were collected, including 30 patients with moderate COPD and 20 patients with severe COPD. Fifty health controls,matched to the cases with gender and age,were included in the study. The serum levels of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), total-antioxidant capability (T-AOC), C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were measured and compared between three groups. Results  The serum levels of SOD, GSH-Px and T-AOC were significantly lower in moderate and severe COPD groups than those of control group, but the serum levels of MDA, CRP, IL-6 and TNF-α were significantly higher than those of control group( P﹤0.001). The serum levels of SOD, GSH-Px and T-AOC were significantly higher in moderate COPD group than those of severe COPD group, but the serum levels of MDA, CRP, IL-6 and TNF-α were significantly lower in moderate COPD group than those of severe COPD group (P﹤0.001). The serum levels of MDA were positively correlated with serum levels of CRP, IL-6 and TNF-α. The serum levels of T-AOC, SOD and GSH-Px were negatively correlated with serum levels of CRP, IL-6 and TNF-α (P < 0.01). Conclusion  The imbalance of oxidant/antioxidant can promote inflammation, which accelerates the onset and progress of inflammatory reaction during acute exacerbation of COPD.

Key words: pulmonary disease, chronic obstructiveoxidative stress malondialdehydesuperoxide dismutase glutathione peroxidaseC-reactive proteininterleukin-6 tumor necrosis factor-alpha, 白细胞介素6