Nrf2/HO-1通路在银屑病中作用的研究进展

doi:10.11958/20231583

天津医药 ›› 2024, Vol. 52 ›› Issue (5): 552-556.doi: 10.11958/20231583

Nrf2/HO-1通路在银屑病中作用的研究进展

黎敏¹(), 龚坚², 吴伟伟³, 刘巧¹^,^△()

1 江西中医药大学（邮编330004）
2 江西省皮肤病专科医院
3 海南省第五人民医院整形与皮肤外科

收稿日期:2023-10-27 修回日期:2023-11-16 出版日期:2024-05-15 发布日期:2024-05-09
通讯作者: ^△ E-mail：drliuqiao@163.com
作者简介:黎敏（1996），女，博士在读，主要从事中西医结合诊疗皮肤病相关研究。E-mail：limin6816@yeah.net
基金资助:
国家自然科学基金资助项目(81860848);江西省自然科学基金青年基金项目(20232BAB216108);江西省卫生健康委科技计划项目(202311334)

Research progress on the role of Nrf2/HO-1 pathway in psoriasis

LI Min¹(), GONG Jian², WU Weiwei³, LIU Qiao¹^,^△()

1 Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
2 Jiangxi Provincial Clinical Research Center for Skin Diseases
3 Department of Plastic and Dermatological Surgery, the Fifth People’s Hospital of Hainan Province

Received:2023-10-27 Revised:2023-11-16 Published:2024-05-15 Online:2024-05-09
Contact: ^△ E-mail：drliuqiao@163.com

黎敏, 龚坚, 吴伟伟, 刘巧. Nrf2/HO-1通路在银屑病中作用的研究进展[J]. 天津医药, 2024, 52(5): 552-556.

LI Min, GONG Jian, WU Weiwei, LIU Qiao. Research progress on the role of Nrf2/HO-1 pathway in psoriasis[J]. Tianjin Medical Journal, 2024, 52(5): 552-556.

摘要/Abstract

摘要：

银屑病的发病机制复杂，探索其发病机制对于治疗十分重要。核因子E2相关因子2（Nrf2）/血红素加氧酶1（HO-1）通路对细胞具有保护作用，与氧化应激、免疫、血管异常增生、表皮失衡以及细胞死亡等生理病理过程密切相关。目前已有研究证实Nrf2/HO-1通路对银屑病皮损有抑制作用，可能通过多种途径参与银屑病发病。就Nrf2/HO-1通路在银屑病中的作用机制及中医药通过干预该通路治疗银屑病的研究进展进行综述。

Abstract:

The pathogenesis of psoriasis is complex, so it is very important to explore the pathogenesis for the treatment of psoriasis. The Nrf2/HO-1 pathway has a protective effect on cells and is closely related to physiological and pathological aspects such as oxidative stress, immunity, abnormal proliferation of blood vessels, epidermal imbalance and cell death. Currently, some studies have confirmed that Nrf2/HO-1 pathway may have an inhibitory effect on psoriatic lesion, and it may be involved in psoriasis pathogenesis through multiple pathways. This paper reviews the mechanism of Nrf2/HO-1 pathway in psoriasis and the research progress in the treatment of psoriasis through the intervention of traditional Chinese medicine.

Key words: NF-E2-related factor 2, heme oxygenase-1, psoriasis, traditional Chinese medicine and pharmacy, oxidative stress, cell death

中图分类号:

R758.63

图/表 1

参考文献 58

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Nrf2/HO-1通路在银屑病中作用的研究进展

Research progress on the role of Nrf2/HO-1 pathway in psoriasis

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