关键词: 糖尿病, 2型, 高血压, 烟酰胺磷酸核糖基转移酶, 肿瘤坏死因子α, 胰岛素, 尿酸, 内脂素

Abstract: [Abstract] Objective  To investigate the changes and significance of serum visfatin, omentin and tumor necrosis factor (TNF)-α in newly diagnosed type 2 diabetic patients (T2DM) with hypertension. Methods  One hundred and six patients with newly diagnosed type 2 diabetes mellitus were divided into two groups, 54 T2DM patients without hypertension (T2DM group) and 52 T2DM patients with hypertension (DM+H group). The values of blood pressure, height, body mass, blood lipids and uric acid were detected in two groups, and oral glucose tolerance test and insulin challenge test were performed as well.Blood samples were collected to determine the fasting blood glucose and blood glucose concentration 120 min after glucose administration, insulin, visfatin, omentin and TNF-α. The body mass index (BMI) and homeostasis model assessment insulin resistance index (HOMA-IR) were also measured. Results   (1) The levels of fasting blood glucose and serum visfatin and TNF-α 120 min after glucose administration were significantly increased in DM+H group than those of T2DM group, but the level of omentin was significantly decreased in DM+H group (P < 0.05). (2) The levels of visfatin and TNF-α were positively correlated with systolic blood pressure, waist circumference, fasting insulin and HOMA-IR, but the level of omentin was negatively correlated with diastolic blood pressure, waist circumference, fasting insulin and HOMA-IR. (3) The multivariate linear regression demonstrated that the level of fasting insulin was influencing factors of fasting and glucose-stimulated visfatin, but systolic blood pressure mainly affected fasting visfatin. The level of fasting omentin was mainly affected by HOMA-IR and diastolic blood pressure, but waist circumference, HOMA-IR and serum uric acid were variables of glucose-stimulated omentin. Values of BMI and fasting insulin were influencing factors of fasting and TNF-α 120 min after glucose administration respectively. Conclusion   The levels of serum visfatin, omentin and TNF-α are significantly changed in newly diagnosed type2 diabetic patients with hypertension, which may be involved in the pathological process of hypertension through many ways.with diastolic blood pressure, waist circumference, fasting insulin and HOMA-IR. ③Multivariate linear regression demonstrated that the levels of fasting insulin were influencing factors of fasting and glucose-stimulated visfatin, but systolic blood pressure mainly affected fasting visfatin; Fasting omentin were mainly affected by HOMA-IR and diastolic blood pressure, but waist circumference, HOMA-IR and serum uric acid were variables of glucose--stimulated omentin.; BMI and fasting insulin were influencing factors of fasting and 120min TNFα respectively. Conclusion The levels of serum visfatin, omentin and TNFα are significantly changed in newly diagnosed type 2 diabetic patients with hypertension, which may be involved in the pathological process of hypertension through many ways.

Key words: diabetes mellitus, type 2, hypertension, nicotinamide phosphoribosyltransferase, tumor necrosis factor-alpha, Insulin, uric acid, 内脂素