天津医药

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儿童自身免疫甲状腺病血清TSAb及TSBAb检测临床意义探讨

何娟1,刘戈力2,刘婷婷1,杨箐岩2,郑荣秀2   

  1. 1. 天津医科大学研究生院
    2. 天津医科大学总医院儿科
  • 收稿日期:2014-06-26 修回日期:2014-07-23 出版日期:2014-11-15 发布日期:2014-11-15
  • 通讯作者: 刘戈力

Clinical Significance of Serum TSAb and TSBAb in Children with Autoimmune Thyroid Disease

HE Juan 1,LIU Ge li2,liu ting ting3,YANG Jing yan2,ZHENG Rong xiu4   

  1. 1. Graduate School, Tianjin Medical University
    2. Department of Pediatrics，General Hospital of Tianjin Medical University
    3. Graduate School, Tianjin Medical University,
    4. Department of Pediatric, General Hospital of Tianjin Medical University
  • Received:2014-06-26 Revised:2014-07-23 Published:2014-11-15 Online:2014-11-15
  • Contact: LIU Ge li

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摘要：

【摘要】 目的 探讨促甲状腺激素受体刺激性抗体（TSAb）， 促甲状腺激素受体刺激阻断性抗体（TSBAb）在儿童 Graves 病（GD）、桥本甲状腺炎（HT）诊治过程中的临床价值与意义。 方法 88 例治疗时间小于 6 个月的自身免疫甲状腺病（AITD）儿童分为 GD 55 例（GD 组）和 HT 33 例（HT 组）， 选择同期健康儿童 38 例（正常组）作为对照。 分别用人血清 TSAb 和 TSBAb ELISA 试剂盒检测 3 组血清 TSAb、TSBAb 的水平， 比较 3 组血清 TSAb、TSBAb 的差异，并分析血清 TSAb、TSBAb 之间的相关性及其与血清游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）、超敏促甲状
腺素（TSH）的关系。 结果 GD 组血清 TSAb 水平高于 HT 组和正常组（均 P<0.05）；HT 组血清 TSBAb 水平高于正常组（P < 0.05）； 血清 TSAb 与 TSBAb 无相关性（P>0.05）， 血清 TSAb、 TSBAb 与 FT3、 FT4、 TSH 均无相关性（ 均 P >0.05）。 结论 TSAb、TSBAb 分别与儿童 GD、HT 的发病密切相关， 在 GD 和 HT 的诊断和治疗中有重要的临床价值

关键词: 格雷夫斯病, 桥本病, 促甲状腺激素受体刺激性抗体, 促甲状腺激素受体刺激阻断性抗体, 自身免疫甲状腺病, 儿童

Abstract:

[Abstract]   Objective   To study clinical value and significance of thyroid receptor stimulating antibody (TSAb) and
thyroid stimulating- blocking antibody (TSBAb) on diagnosis and treatment for children with Graves’ disease (GD) and
Hashimoto’ s thyroiditis (HT).   Methods   Eighty-eight children with autoimmune thyroid disease (AITD) and treatment time less six months were divided into GD group (n=55) and HT group (n=33). Thirty-eight healthy children were used as control (Normal group). Human serum TSAb ELISA kit and human TSBAb ELISA kit were used to detect the serum TSAb and serum TSBAb in three groups. The serum levels of TSAb and TSBAb were compared between three groups. The correlation between TSAb and TSBAb, TSAb/TSBAb and free triiodothyronine three (FT3), free thyroxine (FT4), ultra sensitive thyroid stimulating hormone (TSH) were analyzed.   Results   The serum level of TSAb was significantly higher in GD group than that of HT group and Normal group (P<0.05). The serum level of TSBAb was significantly higher in HT group than that of Normal group (P<0.05). There was no significant correlation between serum TSAb and serum TSBAb (P>0.05). There were no significant correlation between serum TSAb, TSBAb and FT3, FT4, TSH (P>0.05).   Conclusion   TSAb and TSBAb are related to the pathogenesis of GD and HT in children. TSAb and TSBAb have an important clinical value in the diagnosis and treatment for children with GD and HT.

Key words: Graves disease, Hashimoto disease, TSAb, TSBAb, autoimmune thyroid disease, child