天津医药

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白细胞介素-6、白细胞介素-10、肿瘤坏死因子-α与 冠心病关系的初步研究

董军1,姜华2,陈树涛3   

  1. 1. 天津市胸科医院 天津市胸科医院 CICU 科
    2. 天津市胸科医院心内一科
    3. 天津市胸科医院CICU 科
  • 收稿日期:2014-03-17 修回日期:2014-06-17 出版日期:2014-11-15 发布日期:2014-11-15
  • 通讯作者: 董军

The Preliminary Study of the Relationship between IL-6,IL-10,TNF-α and Coronary Artery Disease

Dong Jun 1,JIANG Hua 2,CHEN Shu tao1   

  1. 1. Department of CICU of Tianjin Chest Hospital
    2. Department Cardiology, Tianjin Chese Hospital
  • Received:2014-03-17 Revised:2014-06-17 Published:2014-11-15 Online:2014-11-15
  • Contact: Dong Jun

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摘要：

【摘要】 目的 研究炎症细胞因子白细胞介素（IL）-6、肿瘤坏死因子（TNF）-α、IL-10 等与冠心病（CHD）发病的关系。 方法 选取冠心病患者 628 例， 同期经冠脉造影证实冠脉无狭窄的非冠心病患者 540 例为对照组， 记录患者的资料， 包括年龄、体质指数（BMI）、血糖（Glu）、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）等指标， 同时用酶联免疫吸附试验法检测血清 IL-6、IL-10、TNF-α等炎症因子水平。 结果 CHD 组 BMI、LDL-C、TG 水平均高于对照组， 而 HDL-C 水平低于对照组（均 P<0.05）。 CHD 组血清 IL-6、TNF-α水平均高于对照组， 而 IL-10 低于对照组（均 P<0.05）。 结论 血清 IL-6、TNF-α参与了 CHD 的发生。 血清 IL-10有抑制炎症作用， 可能对血管有保护作用。

关键词: 冠心病, 白细胞介素 6, 白细胞介素 10, 肿瘤坏死因子α

Abstract:

[Abstract]   Objective   To study the relationship between coronary artery disease (CHD ) and interleukin-6 (IL-6),
TNF-α and IL-10.   Methods   Patients with CHD were included in CHD group (n=628) and patients without CHD con?firmed by coronary angiography were selected in control group (n=540) . The recorded data included age, body mass index (BMI) and serum levels of glucose (GLU), total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDLC) and low density lipoprotein-cholesterol (LDL-C). Meanwhile serum levels of IL-6, TNF-α, IL-10 were determined by ELISA.   Results   Serum levels of BMI, LDL-C, TG were higher in CHD group than those in control group（P < 0.01）. The serum level of HDL-C was significantly lower in CHD group than that in control group（P < 0.01）. Serum levels of IL-6（P <0.05）and TNF-α（P <0.01） were higher in CHD group than those in control group. The serum level of IL-10 was significantly lower in CHD group than that in control group（P <0.01）.   Conclusion   IL-6 and TNF-α are involved in the development of CHD. IL-10 can inhibit inflammation and protect vessel integrity

Key words: coronary disease, interleukin-6, interleukin-10, tumor necrosis factor-alpha