天津医药

天津医药 ›› 2014, Vol. 42 ›› Issue (12): 1234-1236.doi: 10.3969/j.issn.0253-9896.2014.12.023

• 应用研究 • 上一篇    下一篇

持续正压通气治疗癫痫合并阻塞性睡眠呼吸暂停综合征

赵勇,时宝林,吴春丽,张晓霞,张言镇   

  1. 潍坊市人民医院
  • 收稿日期:2013-12-10 修回日期:2014-08-11 出版日期:2014-12-15 发布日期:2014-12-15
  • 通讯作者: 时宝林 E-mail:shibaolin1975@sina.com
  • 基金资助:
    潍坊市科学技术发展计划项目

Continuous positive airway pressure treatment for epilepsy coexists with sleep apnea syndrome

ZHAO Yong ,Bao-Lin Shi,WU Chunli ,ZHANG Xiaoxia ,ZHANG Yanzhen   

  1. Neurology Department , Weifang People’ s Hospital, Weifang 261041， China
  • Received:2013-12-10 Revised:2014-08-11 Published:2014-12-15 Online:2014-12-15
  • Contact: Bao-Lin Shi E-mail:shibaolin1975@sina.com

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摘要：

【摘要】 目的 探讨持续正压通气（CPAP）对癫 合并睡眠呼吸暂停综合征（OSA）患者癫 发作频率的影响。方法 42 例癫 合并 OSA 患者根据是否能够耐受呼吸机分为持续正压通气（CPAP）组 20 例和药物组 22 例， CPAP 组给予 CPAP 加抗癫 药物治疗， 药物组给予抗癫 药物治疗， 比较 2 组治疗前与治疗 4 周和 24 周时的癫 发作频率和呼吸暂停低通气指数（AHI）。 结果 2 组治疗前癫 发作频率和 AHI 差异无统计学意义（均 P > 0.05）， CPAP 组在治疗后 4 周和 24 周较治疗前发作频率明显减少（P＜ 0.01）， 而药物组在治疗后 4 周和 24 周较治疗前发作频率无明显减少（P＞ 0.05）， 治疗后 4 周和 24 周时， CPAP 组的癫 发作频率明显低于药物组（P＜ 0.01）， 治疗 24 周后， CPAP 组的 AHI 明显下降（P＜ 0.01）， 而药物组 AHI 无变化（P＞ 0.05）。 结论 CPAP 治疗癫 合并 OSA 患者， 短期和长期均能明显减少癫 发作。

关键词: 睡眠呼吸暂停, 阻塞性, 癫, 连续气道正压通气, 药物疗法

Abstract:

[Abstract] Objective To investigate the effect of continuous positive airway pressure (CPAP) on seizure frequency in epilepsy patients complicated with obstructive sleep apnea (OSA). Methods Subjects were divided into CPAP group (20 subjects) and medication group (22 subjects) according to whether they can tolerate CPAP. CPAP group were treated with CPAP combined with antiepileptic drugs. Medication group were treated with antiepileptic drugs alone. Seizure frequency and apnea- hypopnea index (AHI) were compared between groups before and after 4 weeks and 24 weeks of treatment. Results Baseline seizure frequency and apnea-hypopnea index (AHI) were compared between groups（P＞ 0.05）. A sig? nificant reduction of seizure frequency was observed in CPAP group after 4 weeks and 24 weeks of treatment compared to that before treatment (P＜ 0.01). In medication group, no significant difference in seizure frequency was noted betweem 4 weeks and 24 weeks after treatment compared to that before treatment（P＞ 0.05）. A significant reduction of AHI was ob? served in the CPAP group after 24 weeks of treatment compared to that before treatment (P＜ 0.01), but no change of AHI by treatment was observed in medication group (P＞ 0.05). Conclusion Treatment of OSA in patients complicated with epilep? sy may improve seizure control in short and long term, but longer observation time and more samples are needed for further research.

Key words: obstructive sleep apnea, epilepsy, continuous positive airway pressure, drug therapy