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子宫内膜异位症盆腔痛患者血清雌二醇与TNF-α变化的研究

齐之迎1,尹利荣2   

  1. 1. 天津医科大学第二医院
    2. 天津医科大学第二医院妇科
  • 收稿日期:2013-08-19 修回日期:2013-09-11 出版日期:2014-02-15 发布日期:2014-02-15
  • 通讯作者: 齐之迎

The change of estradiol and TNF alpha levels in the serum of the endometriosis patients with pelvic pain

Li-Rong YIN2   

  • Received:2013-08-19 Revised:2013-09-11 Published:2014-02-15 Online:2014-02-15

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摘要： 摘要 目的：探讨子宫内膜异位症盆腔痛患者血清雌二醇及TNF-α的变化及其相关性。方法：应用酶联免疫吸附法(ELISA) 测定113例 Ems盆腔痛患者(轻度疼痛组37例；中度疼痛组41例；重度疼痛组35例) 及30例非内异症患者(对照组)血清雌二醇及TNF-α水平。结果：轻度疼痛患者雌二醇及TNF-α水平与正常组比较差别无统计学意义（P>0.05）；而中度及重度疼痛患者雌二醇及TNF-α水平均明显高于轻度疼痛者，且重度疼痛者高于中度疼痛者，差别均具有统计学意义（均P<0.05）；在轻度疼痛者中雌二醇与TNF-α水平无相关性（P>0.05）；而在中度及重度疼痛者中雌二醇与TNF-α表达水平均呈正相关（均P<0.05）。结论：中度及重度Ems疼痛患者的雌二醇及TNF-α均明显高于正常者及轻度疼痛者，且表达呈正相关，提示较高浓度雌二醇可通过诱导巨噬细胞、释放TNF-α而在慢性盆腔痛中起作用。

关键词: 子宫内膜异位症, 盆腔痛, 雌二醇, 肿瘤坏死因子α, 血清, 酶联免疫吸附法

Abstract: Abstract Objective: To investigate the levels of estradiol and TNF alpha in the serum of the endometriosis patients with pelvic pain and their correlation. Methods: The levels of estradiol and TNF alpha in the serum of 113 patients with Ems pelvic pain (mild pain group of 37 cases, moderate pain group 41 cases; 35 cases of severe pain group) and 30 women without Ems (control group) were measured with ELISA. Results: No significant difference was found in the levels of estradiol and TNF alpha in the patienrs with mild pain and the normal group(P > 0.05);But in patients with moderate and severe pain,the leves of estradiol and TNF alpha were significantly higher than that of mild pain, and severe pain is higher than that of moderate pain, differences were statistically significant (P < 0.05); In mild pain, estradiol has no correlation with TNF alpha level (P > 0.05), while estradiol in moderate and severe pain is a positive correlation with the expression level of TNF alpha (all P <0.05).Conclusion: The leves of estradiol and TNF alpha in patients with moderate and severe pelvic pain of Ems were significantly higher than normal and mild pain, and the expression was positively correlated, suggests that relatively high concentrations of estradiol can induced macrophage to release TNF alpha , thus play a role in chronic pelvic pain of Ems .

Key words: endometriosis, pelvic pain, estradiol, Tumor necrosis factorα, serum, enzyme linked immunosorbent assay