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XRCC1基因多态性与宫颈鳞癌放疗敏感性的关系

樊晓妹1,李魁秀2,牛书怀2,房朝辉2   

  1. 1. 河北医科大学第四医院妇瘤科
    2. 河北医科大学第四医院
  • 收稿日期:2013-10-22 修回日期:2014-03-17 出版日期:2014-06-15 发布日期:2014-06-15
  • 通讯作者: 樊晓妹

  • Received:2013-10-22 Revised:2014-03-17 Published:2014-06-15 Online:2014-06-15
  • Contact: Xiao-Mei FAN

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摘要： 【摘要】目的 探讨XRCC1基因Arg194Trp、Arg399Gln单核苷酸多态性（SNP）与外生型宫颈鳞状细胞癌放疗敏感性的关系。方法 采用错配扩增聚合酶链式反应（MAMA-PCR）方法检测73例外生型宫颈鳞状细胞癌患者血液标本的XRCC1 Arg194Trp、Arg399Gln两个SNP的基因型频率分布，进一步分析其与宫颈癌放疗敏感性的关系。结果 XRCC1基因Arg194Trp、Arg399Gln基因型完全缓解组和部分缓解组分布情况均无统计学差异（P>0.05）。结论XRCC1基因Arg194Trp、Arg399Gln SNP与外生型宫颈鳞状细胞癌放疗敏感性无相关性。

关键词: 宫颈癌, X-射线交错互补修复基因1, 单核苷酸多态性, 放疗敏感性

Abstract: 【Abstract】Objective To investigate the correlation of XRCC1 Arg194Trp Arg399Gln SNPs with radiotherapy response of squamous cell carcinoma of cervix. Methods Polymorphisms Arg194Trp、Arg399Gln of XRCC1 gene in 73 cervical cancer patients were analyzed by mismatch amplification polymerase chain reaction (MAMA-PCR). Result Response to radiotherapy was not statistically significant in three genotypes, Arg/Arg, Arg/Trp, TrP/Trp of XRCC1 at codon 194(P>0.05).Neither was XRCC1 at codon 399.Conclusion SNP of XRCC1 gene at codon 194 and codon 399 could not predict clinical response of patients with squamous cell carcinoma of cervix to radiotherapy.

Key words: Cervical cancer, X-ray repair cross-complementing gene 1, Single nucleotide polymorphism, Radiothetapy sensitivity