天津医药

天津医药 ›› 2014, Vol. 42 ›› Issue (12): 1193-1201.doi: 10.3969/j.issn.0253-9896.2014.12.013

• 临床研究 • 上一篇    下一篇

CD36 rs3211956和rs7755单核苷酸多态性与早发冠心病的相关性

赵伟伟1,车京津1,张彦彦2,邵元霞3,4,王俊乾1   

  1. 1. 天津医科大学第二医院
    2. 天津医科大学第二医院心脏科
    3.
    4. 天津医科大学
  • 收稿日期:2014-05-09 修回日期:2014-08-18 出版日期:2014-12-15 发布日期:2014-12-15
  • 通讯作者: 赵伟伟 E-mail:weiwei1314weiwei@126.com

The association of CD36 rs7755 and rs3211956 single nucleotide polymorphism with premature coronary heart disease

ZHAO Weiwei 1,CHE Jingjin 1,ZHANG Yanyan 1,SHAO Yuanxia 1,2,WANG Junqian 1   

  1. 1. The Second Hospital of Tianjin Medical University, Tianjin 300211, China
    2.
  • Received:2014-05-09 Revised:2014-08-18 Published:2014-12-15 Online:2014-12-15
  • Contact: ZHAO Weiwei E-mail:weiwei1314weiwei@126.com

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摘要：

【摘要】 目的 探讨早发冠状动脉粥样硬化性心脏病（CHD）的危险因素， 及 CD36 基因 rs7755 和 rs3211956 单核苷酸多态性（SNP）与早发 CHD 的相关性。 方法 连续筛选冠状动脉造影证实的早发冠脉严重三支病变者（病变组） 102 例及冠脉造影正常者（ 正常组） 72 例， 对比 2 组 CHD 的传统危险因素， 并用质谱法检测所有入选者 CD36 rs7755 和 rs3211956 位点基因型， 分析早发 CHD 的独立危险因素。 结果 传统危险因素中， 男性、糖尿病、高血压、高低密度脂蛋白胆固醇（LDL-C）及低高密度脂蛋白胆固醇（HDL-C）是早发 CHD 的独立危险因素。 病变组中 rs3211956 的 GT 基因型分布低于正常组（χ2=8.042， P =0.005）， 而 TT 基因型分布高于正常组（χ2=6.191， P =0.014）； TT 基因型者较含 G 等位基因者的体质指数（BMI）水平增高（P =0.037）。 病变组 rs7755 的 G 等位基因的频率高于正常组（χ2=3.636， P=0.047）； GG 基因型的 BMI 水平高于 A 等位基因携带者（P＜ 0.001）， 而 HDL-C 水平低于另两种基因型者（P＜ 0.001）。 Logistic 回归分析显示在分别调整了混杂因素后， rs3211956 基因型 GG、TT 及 rs7755 基因型 GG、 GA 均为早发 CHD 的独立危险因素。 结论 CD36 rs3211956、rs7755 的 SNP 可能是致早发 CHD 的独立危险因素，且可能通过影响 BMI 和 HDL-C 而影响早发 CHD 的发生。

关键词: rs3211956, rs7755, 单核苷酸多态性, CHD危险因素, 冠心病, 多态性

Abstract:

[Abstract] Objective To investigate the risk factors of premature atherosclerotic three-vessel coronary artery dis? ease (CHD), and the association between single nucleotide polymorphism (SNP) of CD36 rs3211956, rs7755 and premature CHD. Methods Patient with premature three-vessel coronary artery disease (n=102) which were confirmed by consecutive coronary angiogram (lesion group) and patients (n=72) without CHD (control group) were enrolled in the study. Conventional CHD risk factors were compared between the two groups as well as SNPs of CD36 rs3211956 and rs7755 to disclose inde? pendent risk factor for CHD, which were measured by mass spectrometry. Results Among the conventional CHD risk fac? tors, male, HBP, high LDL-C, low HDL-C were independent risk factors of premature CHD. The GT genotype proportion of rs3211956 was significantly lower (χ2=8.042， P =0.005) in the lesion group than that in control group while the TT genotype proportion is significantly higher in lesion group compared with that in control group (χ2=6.191， P =0.014). Patients with the TT genotype have higher score of BMI than patients with GG or GT genotype (P =0.037). The G allele proportion of rs7755 in the lesion group was significantly higher than control group (χ2=3.636, P=0.047). Patients of the GG genotype have higher scores of BMI but lower level of HDL-C than those with AA or AG genotype (P＜ 0.001). Logistic regression analysis re? vealed that after excluding a number of confounding factors, GG and TT genotype of rs3211956 and GG and GA genotype of rs7755 were respectively one of the independent risk factors for premature CHD. Conclusion The SNPs of CD36 rs7755 and rs3211956 may be the independent risk factors of premature coronary heart disease and might affect the the onset of CHD by affectting BMI and HDL-C.

Key words: rs3211956, rs7755, SNPs(Single nucleotide polymorphisms), CHD risk factors, coronary heart disease, polymorphism,