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北京市西城区居民高尿酸血症患病率及其与代谢综合征关系的研究

马萍1,陈莉2,杨培颖2   

  1. 1. 北京市西城区椿树社区卫生服务中心
    2. 北京市椿树社区卫生服务中心
  • 收稿日期:2013-11-25 修回日期:2014-03-10 出版日期:2014-07-15 发布日期:2014-07-15
  • 通讯作者: 马萍

The Correlation between Hyperuricemia and Metabolic Syndrome in the Residents in Xicheng District of Beijing

  • Received:2013-11-25 Revised:2014-03-10 Published:2014-07-15 Online:2014-07-15

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摘要：

【摘要】目的 了解北京市西城区居民高尿酸血症（HUA）的患病情况及其与代谢综合征（MS）的关系。方法分层随机抽取834名常住居民作为调查对象，对其身高、体质量、收缩压（SBP）、舒张压（DBP）、血尿酸（UA）、空腹血糖（FPG）、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）等。根据是否患HUA分为HUA组和非 HUA组。根据MS的4个组分，将调查对象分为：（1）MS0组。不具备MS组分中的任一项。（2）MS1组。具备MS组分中的一项。（3）MS2组。具备MS组分中的两项。（4）MS3组。具备MS组分的三项。（5）MS4组。具备MS组分的四项。分析HUA与MS及其组分的关系。结果调查人群HUA的患病率为12.0%，男性高于女性［21.8%（83/381）vs3.8% （17/453），χ 2 =63.765，P＜0.01］，且各年龄段男性HUA患病率均高于女性（均P＜0.05）；HUA组BMI、SBP、DBP、TC、TG 均高于非HUA组（均P＜0.01），2组间HDL-C和FPG差异无统计学意义。HUA组分别合并超重和（或）肥胖、高血压、高血糖、血脂紊乱的患病率均高于非HUA组（均P＜0.01）。HUA患病率随MS组分的增加逐渐升高（χ 2 =46.347， P＜0.01）。结论HUA与MS关系密切，应注重对UA水平的监测。

关键词: 高尿酸血症, 代谢综合征, 患病率

Abstract:

[Abstract] Objective To investigate the correlation between the prevalence of hyperuricemia (HUA) and metabolic syndrome (MS) in community residents in Xicheng District of Beijing.Methods A total of834permanent residents were se? lected for the survey. The values of height, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), serum uric acid (UA), fasting plasma glucose (FPG), total cholesterol (TC), triglyceride (TG) and high density lipopro? tein-cholesterol (HDL-C) were recorded. Subjects were divided into HUA and non-HUA groups. Based on four components of MS, subjects were divided into (1) MS0group (no any component of MS), (2) MS1group (one component of MS), (3) MS2 group (two components of MS), (4) MS3(three components of MS) and (5) MS4group (four components of MS). The relation? ship of HUA and components of MS was analyzed.Results The total prevalence of hyperuricemia was12.0% in834sub? jects. The prevalence of hyperuricemia were significantly higher in male subjects than those of female subjects［21.8% (83/381) vs3.8% (17/453)，χ 2 =63.765，P＜0.01］. Values of BMI, SBP, DBP, TC and TG were significantly higher in HUA group than those of non-HUA group (P＜0.01). There were no significant differences in levels of HDL-C and FPG between two groups. The prevalence of overweight/obesity, hypertension, hyperglycemia and dyslipidemia were significantly higher in HUA group than those of non-HUA group (P＜0.01). The prevalence of HUA gradually increased with the accumulation of MS components (χ 2 =46.347, P＜0.01). Conclusion Hyperuricemia and metabolic syndrome are closely related. We should pay more attention to monitor the serum uric acid levels.