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正常范围甲状腺激素水平与冠状动脉Gensini评分的相关性分析

肖健勇1,曹路2,丛洪良3   

  1. 1. 天津市胸科医院
    2. 天津市胸科医院心内四科
    3. 天津胸科医院
  • 收稿日期:2013-12-16 修回日期:2014-05-04 出版日期:2014-08-15 发布日期:2014-08-15
  • 通讯作者: 肖健勇

Relationship between Normal Thyroid Hormone Levels with Gensini Coronary Scoring System

XIAO Jianyong ,CAO Lu ,CONG Hongliang   

  • Received:2013-12-16 Revised:2014-05-04 Published:2014-08-15 Online:2014-08-15
  • Contact: XIAO Jianyong

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摘要： 摘要：目的? ?探讨甲状腺功能正常的冠心病患者甲状腺激素水平与冠状动脉Gensini评分关系。方法? ?选取233例均行冠状动脉造影且确诊为冠心病患者，同时测定三碘甲状腺原氨酸(T3)、甲状腺素（T4）、游离甲状腺素(FT4)、游离三碘甲状腺原氨酸(FT3)、促甲状腺激素(TSH)等化验指标，其值均在正常范围,同时通过造影结果计算Gensini积分，依据Gensini积分分为四组并进行积分与各种化验指标的Spearman相关性分析及多元回归分析。结果? ?四组不同病变程度的冠心病患者T3、T4、FT4、TSH，CHO、TG、的差异均无统计学意义（P>0.05），FT3、HDL-C随着冠脉病变程度的增加而降低（P<0.01），年龄、LDL-C随着冠脉病变程度的增加而增加，且有统计学意义（P<0.05）。Gensini积分与FT3、HDL-C呈直线负相关，与年龄、LDL-C呈正相关。年龄、FT3、HDL-C、LDL-C 与Gensini积分呈独立相关。结论?? 在甲状腺功能正常时，FT3 水平与Gensini积分呈负相关且独立相关,FT3可作为冠心病患者病变程度的独立危险因素。

关键词: 甲状腺素, 三碘甲状腺原氨酸, 冠心病, Gensini评分

Abstract: Abstrat：Objective   To study the correlation between normal level of thyroid hormone and gensini coronary scoring system．Methods   233 patients who were treated with CAG and diagnosed of patients with coronary heart disease were divided into 4 groups based on gensini coronary scoring system ,all the patients were determined kinds of index which include triiodothyronine(T3),thyronine(T4),free thyronine(FT4), free triiodothyronine (FT3), thyroid stimulating hormone (TSH) and correlation between thyroid hormone level and gensini coronary scoring system was studied by Spearman correlation analysis and Multiple regression analysis.Results   No significant difference was found in the levels of triiodothyronine(T3),thyronine(T4),freethyronine(FT4),Cholesterol(CHO)andTriglyceride(TG) between the 4 groups(P>0．05).FT3 and HDL-C decreased with the increase of the degree of coronary artery lesions（P<0.01）, AGE and LDL-C increased with the increase of the degreeof coronary artery lesions(P<0.05),there was statistical significance.Negative linear correlation was found between the gensini coronary scoring system and FT3、HDL-c,was positively correlated with age and LDL-C .both the index Was independently correlated to Gensini integral.Conclusion   the lower level of FT3 is an indepent risk factor for lesion severity of CHD．

Key words: thyroxine, triiodothyronine, Coronary artery disease, Gensini score