天津医药

天津医药 ›› 2015, Vol. 43 ›› Issue (11): 1326-1330.doi: 10.11958/j.issn.0253-9896.2015.11.028

• 流行病学调查 • 上一篇    下一篇

新疆哈萨克、 汉族原发性高血压与 Cx37 基因多态性相关性研究

芦碧含， 张文雯， 石文艳， 马克涛， 李丽， 郭淑霞， 司军强△#br#   

  1. 石河子大学医学院生理学教研室， 新疆地方与民族高发病教育部重点实验室(邮编832000)
  • 收稿日期:2015-02-03 修回日期:2015-06-30 出版日期:2015-11-15 发布日期:2015-11-15
  • 通讯作者: 司军强 E-mail:sijunqiang@shzu.edu.cn E-mail:lubihan2012@126.com
  • 作者简介:芦碧含 （1988）， 女， 研究生， 主要从事血管生理学研究
  • 基金资助:
    国家重点基础研究发展计划(973计划)(2012CB26600)； 兵团博士基金项目(2010JC16)； 兵团医药专项(2012BA021, 2010GG34）

Relationship between the Cx37 polymorphism of connexin gene and essential hypertension in Kazak and Han population in Xinjiang#br#

LU Bihan, ZHANG Wenwen, SHI Wenyan, MA Ketao, LI Li, GUO Shuxia, SI Junqiang△   

  1. Department of Physiology, School of Medicine Shihezi University, Shihezi 832000, China
  • Received:2015-02-03 Revised:2015-06-30 Published:2015-11-15 Online:2015-11-15
  • Contact: SI Junqiang E-mail:sijunqiang@shzu.edu.cn E-mail:lubihan2012@126.com

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摘要： 目的 探讨新疆哈萨克族（哈族）、 汉族人群缝隙连接蛋白(Cx)37 基因多态性与原发性高血压（EHT）的相关性。方法 新疆地区 EHT 患者 （EHT 组） 500 例， 哈、 汉族各 250 例； 同期健康体检者 （NT 组） 500 例， 其中哈、 汉族各 250 例。比较 2 族 EHT 组与 NT 组人群年龄、 体质量指数 （BMI）、 收缩压 （SBP） 及舒张压 （DBP） 等一般临床特征情况。Cx37 基因 rs1630310、 rs697372、 rs705193 的单核苷酸多态性（SNP）位点基因多态性， 对疾病人群进行 HardyWeinberg 平衡检测， 计算各组哈族和汉族各位点基因型频率及基因频率差异。结果 哈族、 汉族 EHT 组与 NT 组BMI、 SBP、 DBP、 载脂蛋白比值及同型半胱氨酸差异均有统计学意义(P < 0.05)。EHT 组与 NT 组 rs705193 位点基因型频率和基因频率差异均无统计学意义(P > 0.05)。哈族 rs1630310 位点基因型频率及基因频率差异均有统计学意义(P < 0.01)； 哈族 rs697372 位点基因型频率差异无统计学意义 （P > 0.05） ,但基因频率差异有统计学意义 （P < 0.05），
汉族 2 组 rs1630310、 rs697372 位点基因型频率及基因频率差异均无统计学意义。结论 Cx37 基因多态性与新疆哈族 EHT 的发生有关，rs1630310 及rs697372

关键词: 连接蛋白类, 基因型, 多态性, 单核苷酸, 人种群, 汉族, 原发性高血压, 哈萨克族, 缝隙连接蛋白 37, rs1630310,  rs697372, rs705193

Abstract: Objective To investigate the association of the Cx37 polymorphism of connexin gene with essential hypertension (EHT) in Xinjiang Han and Kazak population. Methods In Xinjiang region, 500 EHT patients (EHT group) were included in this study including Kazak 250 cases and Han 250 cases. Five hundred healthy volunteers (NT) were used as NT group including Kazak 250 cases and Han 250 cases. The values of age, body mass index (BMI), systolic blood pressure (SBP) and diastolic blood pressure (DBP), and other general clinical features were compared between two groups. The polymorphism of Cx37 gene rs1630310, rs697372 and rs705193 SNP were compared between EHT and NT groups in the two ethnic groups. Hardy-Weinberg equilibrium was used to detect the representation, and differences of genotype frequencies and gene frequency were calculated in two groups of Kazak and Han groups. Results There were significant differences in BMI, SBP, DBP, apolipoprotein ratios and homocysteine between EHT group and NT group in Kazak and Han groups (P < 0.05). There were no significant differences in genotype frequencies and gene frequencies of rs705193 between EHT and NT groups (P > 0.05). The differences of Kazak rs1630310 genotype and gene frequency were statistically significant (P < 0.01). The frequency of Kazak rs697372 locus genotype was not significantly different (P > 0.05), but the difference of gene frequency was statistically significant (P < 0.05). There were no significant differences in rs1630310 and rs697372 locus genotype and gene frequency in two groups of Han group. Conclusion Cx37 gene polymorphism is associated with the occurrence of EHT in Xinjiang Kazak population, which may be related with the rs1630310 and rs697372 polymorphism.

Key words: connexins, genotype, polymorphism, single nucleotide, ethnic groups, Han Nationlity, essential hypertertension, Kazak, Cx37, rs1630310, rs697372, rs705193