天津医药

天津医药 ›› 2015, Vol. 43 ›› Issue (7): 784-792.doi: 10.11958/j.issn.0253-9896.2015.07.023

• 应用研究 • 上一篇    下一篇

老年COPD急性加重期合并2型糖尿病患者血浆D-二聚体的动态变化

王彦春，张俊峰，魏殿军，刘春莉   

  1. 1 天津医科大学第二医院（邮编 300211）；
    2 天津医科大学
  • 收稿日期:2014-10-28 修回日期:2014-12-11 出版日期:2015-07-15 发布日期:2015-07-15
  • 通讯作者: 王彦春 E-mail:wyc8882@126.com

The study on dynamic changes of plasma D-dimer in elderly patients with acute exacerbation of COPD combined with type 2 diabetes mellitus

WANG Yanchun, ZHANG Junfeng, WEI Dianjun, LIU Chunli   

  1. 1 The Second Hospital of Tianjin Medical University
    2 Tianjin Medical University

  • Received:2014-10-28 Revised:2014-12-11 Published:2015-07-15 Online:2015-07-15
  • Contact: WANG Yanchun1 E-mail:wyc8882@126.com

PDF (PC)

3954

摘要： 摘要：目的 探讨老年慢性阻塞性肺疾病急性加重期（AECOPD）合并2型糖尿病患者血浆D-二聚体、C-反应蛋白(CRP)、空腹血糖(FBG)水平的动态变化特点。方法 选取单纯AECOPD组（A组）65例和AECOPD合并2型糖尿病组（B组）65例，观察并比较2组入院后第1、3、7、14天D-二聚体、CRP、FBG水平的变化，分析D-二聚体、CRP、FBG的相关关系，Logistic回归分析D-二聚体水平升高的因素。结果 B组D-二聚体、CRP、FBG在入院后第1、3、7天均高于A组（P<0.01）；D-二聚体、CRP值在A组自入院后第7天明显下降,在B组直到第14天明显下降；A组入院后各时间段FBG变化无明显差异，入院后B组FBG呈下降趋势；D-二聚体、CRP、FBG三者间均呈正相关（P<0.05）；CRP、FBG、p（O2）、年龄是影响D-二聚体水平升高的因素。结论 老年AECOPD合并2型糖尿病的患者在抗炎和控制血糖的同时，应注意动态监测D-二聚体水平，有助于改善COPD患者的临床及预后，降低病死率。

关键词: 肺疾病, 慢性阻塞性, 糖尿病, 2型, 老年人, D-二聚体

Abstract: Abstract: Objective to investigate the dynamic changes of the levels of plasma D-dimer, C-reactive protein (CRP) and fasting plasma glucose (FBG) in elderly patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) combined with type 2 diabetes mellitus. Methods AECOPD group(n=65) as A group , AECOPD combined with type 2 diabetes mellitus group(n=65) as B group, The levels of D-dimer, CRP and FBG were observed and compared in the first day, third day, seventh day and the 14th day after hospital admission in two groups, and the correlation analysis between D-dimer, CRP and FBG. Logistic regression analysis of the factors that increased plasma levels of D-dimer. Results The levels of D-dimer, CRP and FBG of B group were higher than A group in the first day, third day and the seventh day after hospital admission（P<0.01）, D-dimer and CRP in A group declined obviously in the seventh day after hospital admission, but in B group declined obviously until the 14th day. In A group there was no significant difference on FBG, In B group FBG significantly decreased. there was a positive correlation between CRP,D-dimer and FBG（P<0.05）.Logistic regression analysis showed that CRP, FBG, p（O2）and age were the influence factors for the increased levels of D-dimer . Conclusion in elderly patients with AECOPD combined with type 2 diabetes mellitus, we should pay attention to anti-inflammatory and controlling blood sugar, at the same time dynamic monitoring for the levels of D-dimer, that help to improve the clinical and prognosis for patients with COPD, and reduce mortality.

Key words: pulmonary disease, chronic obstructive,  diabetes mellitus, type 2,  C-reactive protein,  aged, D-dimer