天津医药

天津医药 ›› 2016, Vol. 44 ›› Issue (1): 29-32.doi: 10.11958/20150236

• 专题研究呼吸系统疾病 • 上一篇    下一篇

吸烟对慢性气道炎症患者FeNO 表达的影响

平淼文,王彦,曹洁△,周宁,王杰,郭美南   

  1. 天津医科大学总医院呼吸科 （邮编300052）
  • 收稿日期:2015-10-19 修回日期:2015-11-04 出版日期:2016-01-15 发布日期:2016-01-15
  • 通讯作者: △通讯作者 E-mail： tjcaojie@sina.com E-mail:tjcaojie@sina.com
  • 作者简介:平淼文 （1986）， 男， 硕士在读， 主要从事慢性阻塞性肺疾病气道炎症研究
  • 基金资助:

    基金项目： 国家 “十二五” 科技支撑计划课题 （2012BAI05B02）

The influence of smoking on FeNO expression in patients with chronic airway inflammation

PING Miaowen, WANG Yan, CAO Jie△, ZHOU Ning, WANG Jie, GUO Meinan   

  1. Department of Respiratory Medicine, General Hospital of Tianjin Medical University, Tianjin 300052, China
  • Received:2015-10-19 Revised:2015-11-04 Published:2016-01-15 Online:2016-01-15
  • Contact: △Corresponding Author E-mail: tjcaojie@sina.com E-mail:tjcaojie@sina.com

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摘要： 摘要: 目的 探讨吸烟对慢性气道炎症患者呼出气一氧化氮 （FeNO） 表达的影响。方法 206 例患者根据临床病史及肺功能特点， 分为慢性阻塞性肺病-哮喘重叠综合征 （ACOS） 组 37 例、 慢性阻塞性肺病 （COPD） 组 124 例、 哮喘组 45 例。将健康体检者 40 例作为对照组。然后根据吸烟情况将 4 组内人群划分为吸烟者与不吸烟者。比较 4 组间 FeNO 值、 肺功能指标， 同时比较 4 组内吸烟、 不吸烟者的 FeNO 值； 将每组吸烟者的吸烟指数与 FeNO 值进行相关性分析。结果 （1） ACOS 组与哮喘组 FeNO 值明显高于 COPD 组与对照组 （32.6±9.9、 37.6±10.9 vs 18.7±9.8、 14.4±4.3， F=68.082， P < 0.05）， 而 ACOS 组与哮喘组、 COPD 组与对照组 FeNO 值比较差异无统计学意义。（2） ACOS 组、 COPD 组、 哮喘组的 1 秒用力呼气量占预计值百分比 （FEV1%）、 1 秒用力呼气量占用力肺活量的百分比 （FEV1/ FVC） 均低于对照组， ACOS 组、 COPD 组的 FEV1/FVC 显著低于哮喘组 （P < 0.05）， ACOS 组、 COPD 组、 哮喘组的 FEV1%无明显差异 （P > 0.05）。（3） COPD 组、 ACOS 组吸烟者 FeNO 值均明显低于不吸烟者 （P < 0.05）， 哮喘组、 对照组吸烟者与不吸烟者 FeNO 值无显著性差异 （P > 0.05）。（4） COPD 组吸烟指数与 FeNO 值呈明显负相关， 其他组则无明显相关关系。结论 吸烟可以导致 COPD、 ACOS 患者的 FeNO 值降低， 检测 FeNO 有助于鉴别 COPD 合并哮喘情况。

关键词: 吸烟, 慢性气道炎症, 慢性阻塞性肺病, 呼出气一氧化氮, 吸烟指数

Abstract: Abstract: Objective To discuss the influence of smoking on fractional exhaled nitric oxide (FeNO) expression in pa⁃ tients with chronic airway inflammation. Methods According to the clinical history and characteristics of lung function, 206 patients were divided into asthma and chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) group (n=37), COPD group (n=124) and asthma group (n=45). Meanwhile, 40 people accepted healthy physical examination were used as the control group (n=40). Then persons were sub-divided into smokers or nonsmokers according to the situation of smoking. The FeNO value and pulmonary function index were compared between the four groups, and the FeNO value was compared between smokers and nonsmokers respectively. The smoking index and FeNO value of smokers were measured for correlation analysis. Results (1)The FeNO values were significantly higher in ACOS group and asthma group than those of COPD group and the control group (32.6±9.9 and 37.6±10.9 vs 18.7±9.8 and 14.4±4.3， F=68.082， P < 0.05). However, there were no significant differences in FeNO value between ACOS group and asthma group, and between COPD group and the control group. (2) The FEV1/FVC was significantly lower in ACOS group, COPD group and asthma group than that of control group, while the FEV1/FVC was significantly lower in ACOS group and COPD group than that of asthma group（P < 0.05). There was no significant difference in FEV1% between ACOS group, COPD group and asthma group（P > 0.05). (3) The Fe⁃ NO value was significantly lower in smokers of COPD group and ACOS group than that of non-smokers （P < 0.05). However, there was no significant difference in FeNO value between smokers and nonsmokers in asthma group and the control group （P > 0.05). (4)The smoking index and FeNO value were negatively correlated in COPD group, but there were no obvious cor⁃ relation in smoking index and FeNO values between other groups. Conclusion Smoking can lead to the reduction of FeNO value in COPD and ACOS patients. The detection of FeNO is helpful for the differentiating COPD combined asthma.

Key words: smoking, chronic airway inflammation, chronic obstructive pulmonary disease, FeNO, smoking index