天津医药

天津医药 ›› 2016, Vol. 44 ›› Issue (2): 250-252.doi: 10.11958/58912

• 综述 • 上一篇    下一篇

富氢生理盐水治疗相关疾病机制研究进展

李波 1,吕国义 1， 于泳浩 2△， 谢克亮 2， 王国林 2   

  1. 1天津医科大学第二医院麻醉科 （邮编300211）； 2天津医科大学总医院麻醉科
  • 收稿日期:2015-05-08 修回日期:2015-10-27 出版日期:2016-02-15 发布日期:2016-02-15
  • 通讯作者: △通讯作者 E-mail： yuyonghao@126.com E-mail:libohike1020@sina.com
  • 基金资助:
    天津市卫生局科技基金资助项目(2014KZ094)

Research progress of hydrogen-rich saline for the treatment of diseases

LI Bo1, LYU Guoyi1, YU Yonghao2△, XIE Keliang2, WANG Guolin2   

  1. 1 Department of Anesthesiology, the Second Hospital of Tianjin Medical University, Tianjin 300211, China； 2 Department of Anesthesiology, General Hospital of Tianjin Medical University
  • Received:2015-05-08 Revised:2015-10-27 Published:2016-02-15 Online:2016-02-15
  • Contact: △Corresponding Author E-mail: yuyonghao@126.com E-mail:libohike1020@sina.com

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摘要： 氧化应激、 炎症因子、 细胞的凋亡参与多种疾病的发生、 发展。近年来研究发现， 富氢盐水可通过抗氧化 应激反应、 抗炎反应、 抗凋亡作用治疗多种疾病， 如缺血/再灌注引发的重要脏器的损伤、 神经退行性疾病、 脓毒血症、 神经病理性痛、 多器官衰竭等疾病。本文对富氢盐水治疗疾病的相关机制进行综述。

关键词: 细胞凋亡, 氧化性应激, 综述, 富氢生理盐水, 炎症因子

Abstract: The oxidative stress, inflammatory cytokines and apoptosis have been strongly implicated in the pathogenesis of multiple diseases. Recently, more and more research findings have demonstrated that hydrogen-rich saline (HRS) has the anti-oxidant, anti-inflammatory and anti-apoptotic effects in vivo and in vitro, and can be used to treat multiple diseases, such as ischemia/reperfusion injury, stroke, neurodegeneration, sepsis, neuropathic pain and multiple organ dysfunction syndrome diseases. This article reviews the possible mechanism of HRS for the treatment of diseases.

Key words: apoptosis, oxidative stress, review, hydrogen-rich saline, inflammatory cytokines