天津医药 ›› 2017, Vol. 45 ›› Issue (2): 191-196.doi: 10.11958/20160750

• 临床研究 • 上一篇    下一篇

冠状动脉旁路移植术后晚期静脉移植血管病与血常规指标的相关性

孙博 1, 刘寅 2△, 高静 2, 孙根义 2   

  1. 1 天津医科大学 (邮编 300070); 2 天津市胸科医院心内科
  • 收稿日期:2016-08-04 修回日期:2017-01-11 出版日期:2017-02-15 发布日期:2017-02-14
  • 通讯作者: △通迅作者 E-mail:Liuyin2088@163.com E-mail:sunbo890323@aliyun.com
  • 作者简介:孙博 (1989), 男, 硕士在读, 主要从事心血管疾病方面研究
  • 基金资助:
    天津市科技支撑计划重点项目(16YFZCSY00800); 天津市卫生行业重点攻关项目(15KG128); 天津市卫计委科技基金项目(2015KY35)

The relation between blood routine test indicators and advanced saphenous vein graft disease in patients with coronary artery bypass grafting

SUN Bo1, LIU Yin2△, GAO Jing2, SUN Gen-yi2   

  1. 1 Tianjin Medical University, Tianjin 300070, China; 2 Department of Cardiology, Tianjin Chest Hospital
  • Received:2016-08-04 Revised:2017-01-11 Published:2017-02-15 Online:2017-02-14
  • Contact: △Corresponding Author E-mail:Liuyin2088@163.com E-mail:sunbo890323@aliyun.com

摘要: 目的 探讨冠状动脉旁路移植术(CABG)后晚期静脉移植血管病(SVGD)与血常规指标的关系。方法连续入选 2015 年 3 月—2016 年 1 月于天津市胸科医院就诊并行静脉移植血管(SVG)的冠状血管造影术(CAG)检查的 CABG 术后超过 1 年的再发胸痛患者, 将 CABG 术后 SVG 狭窄≥50%、 除外吻合口狭窄的病变定义为 SVGD, 根据 CAG 结果, 将患者分为 SVGD 组及非 SVGD 组。对比 2 组患者血常规化验结果, 采用多因素 Logistic 回归分析血常规指标与晚期 SVGD 发生的关系。结果 共入选患者 148 例, 其中 SVGD 组 109 例、 非 SVGD 组 39 例。对比发现 SVGD 组和非 SVGD 组红细胞分布宽度(RDW: 0.123 2±0.008 9 vs. 0.120 2±0.005 2)、 中性粒细胞与淋巴细胞比值(NLR: 3.40±2.11 vs. 2.75±0.82)和血小板计数与淋巴细胞比值(PLR: 143.10±54.70 vs. 124.57±34.40)差异均有统计学意义(P<0.05)。多因素 Logistic 回归分析显示, RDW>0.127 5[OR(95%CI): 4.905(1.058~22.747), P=0.042]、 NLR> 3.34[OR(95%CI): 4.013(1.466~10.987), P=0.007]是晚期 SVGD 的独立危险因素, 血小板比容(PCT) >0.185[OR (95%CI): 2.636 (1.098~6.324), P=0.030] 可能成为晚期 SVGD 的危险因素。结论 RDW>0.127 5、 NLR>3.34 可提示晚期 SVGD, PCT>0.185 用于预测晚期 SVGD 需更大样本量的研究支持。

关键词: 冠状动脉旁路移植术, 非体外循环, 冠状血管造影术, 静脉移植血管病, 血常规, 危险因素

Abstract: Objective To investigate the correlation between blood routine test indicators and advanced saphenous vein graft disease (SVGD) in patients with coronary artery bypass grafting (CABG). Methods By defining SVGD as an occlusion of 50% or more of the saphenous vein graft (SVG) excluding distal anastomotic occlusion, patients were divided into SVGD group and non- SVGD group, who suffered CABG over 1 year with recurrent angina and underwent coronary angiography (CAG) operation from March 2015 to January 2016 in Tianjin Chest Hospital. Results of blood routine test data were compared between two groups. The multivariable Logistic regression was analyzed for the relationship between blood routine test indicators and advanced SVGD. Results There were 148 patients in the study, 109 patients in SVGD group and 39 patients in non-SVGD group. There were significant differences in level of red blood cell distribution width (RDW: 0.123 2±0.008 9 vs. 0.120 2±0.005 2, P<0.05), neutrophil/lymphocyte ratio (NLR: 3.40±2.11 vs. 2.75±0.82, P<0.05) and platelet and lymphocyte ratio (PLR: 143.10±54.70 vs. 124.57±34.40, P<0.05) between SVGD group and non-SVGD group. Multivariable Logistic regression analysis showed that RDW>0.127 5[OR (95%CI): 4.905 (1.058-22.747), P=0.042] , NLR> 3.34[OR(95%CI): 4.013(1.466-10.987), P=0.007] were independent risk factors for advanced SVGD, as well as PCT>0.185 [OR(95%CI): 2.636(1.098-6.324), P=0.030]might be risk factor for advanced SVGD. Conclusion RDW>0.127 5, NLR> 3.34 could indicate advanced SVGD. We need more samples to support that PCT>0.185 is used to be risk indicators for advanced SVGD.

Key words: coronary artery bypass grafting, off- pump, coronary angiography, saphenous vein graft disease, blood routine test, risk factor