天津医药

天津医药 ›› 2017, Vol. 45 ›› Issue (3): 282-284.doi: 10.11958/20161196

• 临床研究 • 上一篇    下一篇

牙周基础治疗对行腹膜透析牙周炎患者的影响

张晋玮 1,2， 刘建山 1， 马明 1， 侯晓艳 1， 郭乐乐 1， 彭诚 1△   

  1. 1 天津医科大学第二医院 （邮编 300211）； 2 天津市第三中心医院分院
  • 收稿日期:2016-10-21 修回日期:2016-12-12 出版日期:2017-03-15 发布日期:2017-03-21
  • 通讯作者: 彭诚 E-mail:zhangjinwei0423@163.com

Effects of periodontal basic treatment on peritoneal dialysis in patients with periodontitis

ZHANG Jin-wei1,2, LIU Jian-shan1, MA Ming1, HOU Xiao-yan1, GUO Le-le1, PENG Cheng1△   

  1. 1 The Second Hospital of Tianjin Medical University, Tianjin 300211, China; 2 Tianjin Third Hospital Branch
  • Received:2016-10-21 Revised:2016-12-12 Published:2017-03-15 Online:2017-03-21
  • Contact: PENG Cheng E-mail:zhangjinwei0423@163.com

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摘要： 摘要： 目的 探讨牙周基础治疗对行腹膜透析牙周炎患者牙周局部及全身炎症反应的影响。方法 在肾内科行规律性腹膜透析患者中选择伴发牙周炎的患者 61 例， 随机分为 2 组。观察组 31 例， 行牙周基础治疗（超声龈上洁治、 龈下刮治、 超声龈下药物冲洗、 根面平整术、 口腔卫生宣教）和腹膜透析治疗； 对照组 30 例仅行腹膜透析治疗。分别于治疗前和治疗 1 个月后， 检查 2 组的菌斑指数（PLI）、 牙龈指数（GI）、 牙周探诊深度（PD）； 并取龈沟液样本及血清样本， 采用免疫透射比浊法测量超敏 C 反应蛋白（hs-CRP）的水平。结果 治疗前， 2 组的 PLI、 GI、 PD、 龈沟液 hs-CRP、 血清 hs-CRP 的差异无统计学意义； 治疗 1 个月后， 观察组的各项指标均下降，且观察组的各项指标低于对照组； 对照组的 PLI、 PD、 GI 及龈沟液中和静脉血中的 hs-CRP 水平与治疗前比较差异无统计学意义。结论 牙周基础治疗不仅可以改善行腹膜透析牙周炎患者的牙周局部炎症状况， 而且可以降低全身炎性因子 hs-CRP 的水平， 降低感染风险。

关键词: 腹膜透析, 牙周炎, 牙周基础治疗, 超敏 C 反应蛋白

Abstract: Abstract: Objective To investigate the local or systemic effects of initial periodontal therapy on peritoneal dialysis in patients with chronic kidney disease and periodontitis. Methods Sixty-one patients with both periodontitis and regular peritoneal dialysis were selected in this study and were randomly divided into observation group (n=31) and control group (n=30). Patients in observation group were given periodontal initial therapy (ultrasonic supragingival scaling and ultrasonic subgingival irrigation, drug, root planing, oral health education) and peritoneal dialysis treatment. Patients in control group were given only peritoneal dialysis treatment. Clinical parameters including plaque index (PLI), gingival index (GI) and probing depth (PD) were detected before and one month after treatment in two groups. The concentrations of high-sensitivity C-reactive protein (hs-CRP) in gingival sulcus fluid and serum samples were measured by immune transmission turbidity method in two groups. Results There were no significant differences in PLI, GI, PD, hs-CRP of gingival sulcus fluid, and serum hs-CRP before treatment between the two groups. After one-month initial therapy, all the indexes were decreased in observation group, which were significantly different compared with those before treatment (P＜0.05). And all the indexes were significantly lower in observation group than those of control group. There were no significant differences in PLI, PD,GI, hs- CRP of gingival sulcus fluid, and serum hs- CRP between control group and observation group before treatment.Conclusion Periodontal initial treatment can improve the periodontal inflammation in patients with chronic kidney disease, and reduce the concentration of systemic inflammatory factor hs-CRP, decreasing the risk of infection.

Key words: peritoneal dialysis, periodontitis, basic treatment, high sensitivity C-reactive protein