天津医药

天津医药 ›› 2016, Vol. 44 ›› Issue (10): 1287-1290.doi: 10.11958/20160541

• 综述 • 上一篇    下一篇

microRNAs与腹膜纤维化的研究进展

李栋,闫铁昆   

  1. 天津医科大学总医院肾内科（邮编 300052）
  • 收稿日期:2016-06-12 修回日期:2016-08-11 出版日期:2016-10-15 发布日期:2016-10-21
  • 通讯作者: 闫铁昆 E-mail:lidong430@126.com
  • 作者简介:李栋（1978）， 男， 博士， 主要从事腹膜纤维化和糖尿病肾病研究
  • 基金资助:

    天津市应用基础与前沿技术研究计划项目（15JCYBJC26200）

Research on the relationship between miRNAs and peritoneal fibrosis

LI Dong， YAN Tiekun   

  1. Department of Nephrology, Tianjin Medical University General Hospital, Tianjin 300052, China
  • Received:2016-06-12 Revised:2016-08-11 Published:2016-10-15 Online:2016-10-21
  • Contact: YAN Tiekun E-mail:lidong430@126.com

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摘要： 近年发现微小 RNA（miRNAs）是转录后基因调控的关键因素， 参与诸多疾病的发生、发展。 腹膜透析是终末期肾脏疾病的主要替代治疗方法之一， 腹膜纤维化是导致腹透患者退出腹透治疗的最主要因素， 制约了腹膜透析的应用和发展。 miRNAs 与腹膜纤维化发生密切相关。 本文就 miRNAs 在腹膜纤维化发病机制及治疗中的作用进行综述。

关键词: 微 RNAs, 腹膜后纤维化, 间质细胞, 腹膜透析, 综述, 上皮间充质转分化

Abstract: In recent years, microRNAs were found to be one of the key factors in post transcriptional gene regulation which are involved in occurrence,development of many diseases. Peritoneal dialysis has become an effective alternative treatment approaches for patients with ESRD. Peritoneal fibrosis is one of the most important factors forced patients with ESRD to interrupt from long-term peritoneal dialysis, hence restricts the application and development of peritoneal dialysis.MicroRNAs are closely related to peritoneal fibrosis. This article reviews the role of microRNAs in the pathogenesis and treatment of peritoneal fibrosis.

Key words: microRNAs, retroperitoneal fibrosis, stromal cells, peritoneal dialysis, review, epithelial mesenchymal transdifferentiation