摘要： Objective To investigate the clinical value of prognostic nutritional index (PNI), neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in all-cause mortality of patients with peritoneal dialysis (PD). Methods A total of 189 patients who received PD were divided into the death group (n=71) and the survival group (n=118) according to whether they died during follow-up. The differences of clinical indicators between the two groups were compared. The clinical value of PNI score, NLR and PLR in predicting the death of PD patients was analyzed by receiver operating characteristic (ROC) curve. Multivariate Cox regression model was used to analyze the risk factors for death. Kaplan-Meier method was used to compare the survival differences of patients with different PNI scores, NLR and PLR levels. Results Compared with the survival group, patients were older, the proportion of patients with hypertension and diabetes increased, the NLR and PLR were increased, and the PNI was decreased in the death group (P<0.05). The ROC curve results showed that the area under the ROC curve (AUC) of NLR, PLR and PNI in predicting all-cause death in peritoneal dialysis patients were 0.684, 0.689 and 0.729, respectively, and the sensitivity were 57.75%, 67.61% and 57.75%, respectively. The specificity were 79.66%, 68.64%, 80.51%, and the optimal cut-off values were NLR=4.91, PLR=152.92, PNI=43.74, respectively. Cox regression analysis showed that increased NLR (HR=2.271, 95%CI: 1.375-3.753), increased PLR (HR=2.846, 95%CI: 1.672-4.844) and decreased PNI (HR=2.802, 95% CI: 1.701-4.616) were risk factors for all-cause mortality in PD patients. Survival analysis showed that the cumulative survival rates of patients with NLR≥4.91, PLR≥152.92 and PNI≤43.74 were significantly decreased (Log rank χ²= 23.299, 20.625, 28.183, P<0.01). Conclusion PNI combined with NLR and PLR has a good predictive effect on the prognosis of PD patients.

中图分类号: 

• R459.51