天津医药

天津医药 ›› 2018, Vol. 46 ›› Issue (12): 1352-1356.doi: 10.11958/20181167

• 综述 • 上一篇    下一篇

髓系抑制性细胞在肝癌发病中的作用研究进展

张新羽，闫会敏   

  1. 1河北医科大学研究生学院（邮编050017）；2石家庄市第五医院临床医学研究中心
  • 收稿日期:2018-08-03 修回日期:2018-09-18 出版日期:2018-12-15 发布日期:2019-01-24
  • 通讯作者: 闫会敏 E-mail:yanhm2538@163.com

Advances in the role of myeloid derived suppressor cells in the pathogenesis of hepatocellular carcinoma

ZHANG Xin-yu,YAN Hui-min   

  1. 1 Graduate College of Hebei Medical University, Shijiazhuang 050017, China;2 Clinical Research Center, Shijiazhuang Fifth Hospital
  • Received:2018-08-03 Revised:2018-09-18 Published:2018-12-15 Online:2019-01-24

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摘要： 髓系抑制性细胞（MDSCs）是备受关注的免疫抑制性细胞，具有调节免疫应答的作用。近年发现MDSCs与肝癌发生发展及预后密切相关，肝癌微环境中多种因子影响MDSCs的扩增、活化和募集，而MDSCs通过下调机体的抗肿瘤免疫应答或诱导免疫耐受形成，促进肿瘤的生长与转移。研究MDSCs在肝癌免疫逃逸的作用，将为肝癌早期发现、诊断及免疫治疗等提供新线索。

关键词: 肝肿瘤, 髓系细胞, 抑制因子, 免疫, 肿瘤逃逸, 综述, 微环境

Abstract: Myeloid derived suppressor cells (MDSCs) are immunosuppressor cells that have attracted much attention and play a role in regulating immune response. Recently, accumulating evidence has demonstrated that MDSCs are closely related to the development and prognosis of hepatic cancer. Multiple factors in the microenvironment of hepatic cancer affect the expansion, activation and recruitment of MDSCs, while MDSCs promote tumor growth and metastasis by downregulating antitumor immune response or inducing immune tolerance. The study on effect of MDSCs on immune escape of hepatic cancer will provide new clues for early detection, diagnosis and immunotherapy of hepatic cancer.

Key words: liver neoplasms, myeloid cells, suppressor factors, immunologic, tumor escape, review, microenvironment