天津医药

天津医药 ›› 2018, Vol. 46 ›› Issue (3): 288-291.doi: 10.11958/20170951

• 临床研究 • 上一篇    下一篇

红光照射疗法治疗带状疱疹后遗神经痛的效果及对患者生活质量的影响

吴英桂，欧伟洪   

  1. 1海口市第三人民医院皮肤科（邮编571100）；2海口市人民医院皮肤科
  • 收稿日期:2017-09-07 修回日期:2017-12-25 出版日期:2018-03-15 发布日期:2018-03-23
  • 通讯作者: 吴英桂 E-mail:76904350@qq.com

The effect of red light irradiation therapy on postherpetic neuralgia and its effect on life quality of patients

WU Ying-gui, OU Wei-hong   

  1. 1 Department of Dermatology, Third People’s Hospital of Haikou, Haikou 571100, China;2 Department of Dermatology, Haikou People’s Hospital
  • Received:2017-09-07 Revised:2017-12-25 Published:2018-03-15 Online:2018-03-23

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摘要： 目的 探讨红光照射治疗带状疱疹后遗神经痛的效果及对患者生活质量的改善作用。方法 选取 2013年 1 月—2016 年 8 月我院诊治的带状疱疹后遗神经痛患者 90 例，随机分为红光组 45 例和对照组 45 例，对照组口服加巴喷丁 400 mg，每日 1 次，连续治疗 14 d；红光组在常规药物治疗的基础上，联合红光照射治疗，每日照射治疗15~30 min，每日 1 次，连续治疗 10 d。采用生物酶联免疫吸附试验检测治疗前、后患者血清白细胞介素（IL）-2、IL-6、IL-10 水平，采用视觉模拟评分法（VAS）对患者的疼痛程度进行评价，采用皮肤病生活质量指数（DLQI）评价患者生活质量。结果 治疗前，红光组和对照组的血清 IL-2、IL-6、IL-10 的水平差异无统计学意义；治疗后，红光组的血 清 IL-2、IL-10 水平均高于对照组（P＜0.05），IL-6 水平低于对照组（P＜0.05）；治疗前，红光组和对照组的 VAS 评分差异无统计学意义；治疗后，红光组的 VAS 评分低于对照组（P＜0.05）；治疗前，红光组和对照组 DLQI 各项目评分差异无统计学意义；治疗后，红光组的 DLQI 各项目评分均低于对照组（P＜0.05）。结论 红光照射治疗带状疱疹后遗神经痛能促进疼痛缓解，改善患者的生活质量。

关键词: 疱疹, 带状, 神经痛, 带状疱疹后, 白细胞介素类, 生活质量, 红光照射

Abstract: Objective To investigate the effect of red light irradiation therapy on postherpetic neuralgia and the improvement in the life quality of patients. Methods Ninety patients with postherpetic neuralgia diagnosed and treated in our hospital from January 2013 to August 2016 were randomly divided into red light irradiation group (n=45) and control group (n=45). The control group was given gabapentin 400 mg once daily for 14 days. On the basis of routine drug treatment,the red light irradiation group was treated with red light irradiation for 15-30 minutes, once daily for 10 days. The serum levels of interleukin (IL)-2, IL-6 and IL-10 were detected by enzyme-linked immunosorbent assay (ELISA). The intensity of pain was evaluated by VAS score, and the quality of life was assessed by DLQI. Results Before treatment, there were no significant differences in serum levels of IL-2, IL-6 and IL-10 between two groups. After treatment, the serum levels of IL-2 and IL-10 were significantly higher in red light irradiation group than those of the control group (P＜0.05), and the level of IL-6 was significantly lower in red light irradiation group than that of the control group (P＜0.05). Before treatment, there was no significant difference in the VAS score between the two groups. After treatment, the VAS score was significantly lower in the red light irradiation group than that of the control group (P＜0.05). Before treatment, there were no significant differences in DLQI scores between the two groups. After treatment, the DLQI scores were significantly lower in the red light irradiation group than those in the control group (P＜0.05). Conclusion The treatment of postherpetic neuralgia with red light irradiation can provide effective relief of pain and improve the life quality of patients.

Key words: herpes, banded, neuralgia, herpes zoster, interleukin, quality of life, red light irradiation