天津医药

天津医药 ›› 2019, Vol. 47 ›› Issue (12): 1273-1276.doi: 10.11958/20191892

• 综述 • 上一篇    下一篇

基因修饰的脂肪间充质干细胞的研究进展

张晶莹1，孙晓林2，耿立霞1△   

  1. 1内蒙古科技大学包头医学院第一附属医院重症医学科（邮编014010），2中心实验室
  • 收稿日期:2019-07-01 修回日期:2019-08-19 出版日期:2019-12-15 发布日期:2019-12-15
  • 通讯作者: 耿立霞 E-mail:genglixia8252@sina.com
  • 作者简介:张晶莹（1992），女，硕士在读，主要从事间充质干细胞的治疗研究
  • 基金资助:
    脂肪间充质干细胞来源的外泌体介导硬皮病模型小鼠治疗作用的机制研究;过表达PD-1对脂肪间充质干细胞免疫调控能力的影响;间充质干细胞对免疫系统疾病（系统性红斑狼疮）调控机制的研究与临床应用

Research progress in genetically modified adipose tissue-derived stem cells

ZHANG Jing-ying1, SUN Xiao-lin2, GENG Li-xia1△   

  1. 1 Department of Intensive Medicine, 2 Key Autoimmunity Laboratory of Inner Mongolia, Institute of Rheumatology, Department of Rheumatology, the First Affiliated Hospital of Baotou Medical College, Baotou 014010, China
  • Received:2019-07-01 Revised:2019-08-19 Published:2019-12-15 Online:2019-12-15
  • Supported by:
     

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摘要： 脂肪间充质干细胞（ADSCs）是来源于脂肪组织的具有多向分化潜能的细胞群，是细胞疗法的理想来源。 基因修饰的脂肪间充质干细胞不仅具有ADSCs的全部特性，而且能够高效表达某些外源基因，加强其在疾病治疗中 的疗效，为常规的临床治疗方法难以治愈的疾病带来了新的转机。本文就近年来的相关进展进行综述，以期为基因 修饰的ADSCs在临床研究的应用上提供借鉴。

关键词: 脂肪间充质干细胞, 基因修饰, 多向分化, 综述

Abstract: Adipose mesenchymal stem cells (Adipose tissue-derived stem cells, ADSCs) are multidirectional differentiation potential cells from adipose tissue and are ideal sources of cell therapy. Genetically modified adipose mesenchymal stem cells not only have all the characteristics of ADSCs, but also can express some foreign genes efficiently and enhance their curative effect in the treatment of diseases, which brings a new opportunity for conventional clinical treatment of diseases which are difficult to cure. In this paper, the related progress in recent years is reviewed in order to provide reference for the application of gene modified ADSCs in clinical research.

Key words: adipose tissue-derived stem cells, gene modification, multiple differentiation, review

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