天津医药

天津医药 ›› 2019, Vol. 47 ›› Issue (3): 329-332.doi: 10.11958/20182004

• 综述 • 上一篇    下一篇

NLRP3炎症小体与心房颤动的研究进展

吴小寒，刘长乐   

  1. 天津市心血管病离子与分子机能重点实验室，天津心脏病学研究所，天津医科大学第二医院心脏科（邮编300211）
  • 收稿日期:2018-12-12 修回日期:2019-01-11 出版日期:2019-03-15 发布日期:2019-04-24
  • 通讯作者: 刘长乐 E-mail:lcl1979_2001@163.com

Advances in NLRP3 inflammasome and atrial fibrillation

WU Xiao-han,LIU Chang-le   

  1. Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Tianjin Institute of Cardiology, Department of Cardiology, the Second Hospital of Tianjin Medical University, Tianjin 300211, China
  • Received:2018-12-12 Revised:2019-01-11 Published:2019-03-15 Online:2019-04-24
  • Contact: LIUCHANGLE E-mail:lcl1979_2001@163.com

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摘要： 心房颤动（AF）是临床最常见的快速性心律失常，其发生机制尚未完全阐明，而炎症反应增强常与AF的发生发展相关。核苷酸结合寡聚化结构域受体蛋白3（NLRP3）作为近年研究最为广泛最具特征性的炎症小体，参与诸多非感染性炎性反应。有证据显示其与心房重构、心肌纤维化密切相关，以此入手可为阐明AF的上游机制提供新的理论基础和研究靶点。本文简述了NLRP3的特性及信号传导途径，从基础和临床研究两方面总结了NLRP3与AF的相关性，并对未来NLRP3拮抗剂的应用作出了展望。

关键词: 心房颤动, 信号传导, 核苷酸结合寡聚化结构域受体蛋白3, 综述

Abstract: Atrial fibrillation (AF) is the most common tachyarrhythmia in clinic, but its mechanism has not been fully elucidated, and the increased inflammatory response is often associated with the occurrence and development of AF. As the most widely studied and characteristic inflammatory body in recent years, nucleotide-binding oligomerization domain-like receptor protein3 (NLRP3) inflammasome participates in many non-infectious inflammatory reactions, while more evidences show that NLRP3 is closely related to atrial remodeling and myocardial fibrosis, which may provide a new theoretical basis and research target for the upstream mechanisms of AF. In this paper, the characteristics and signal transduction pathways of NLRP3 are briefly described, the correlation between NLRP3 and AF is summarized from both basic and clinical studies,and the future application of NLRP3 antagonist is prospected.

Key words: atrial fibrillation, signal transduction, NLRP3, review