天津医药

天津医药 ›› 2019, Vol. 47 ›› Issue (4): 440-444.doi: 10.11958/20181917

• 综述 • 上一篇    下一篇

肠道菌群及其代谢产物氧化三甲胺与心力衰竭关系的研究进展

郭攀 1,2，冯津萍 3△，冯超 3，陈树涛 3   

  1. 1天津医科大学胸科临床学院（邮编300222）；2天津医科大学研究生院；3天津市胸科医院CICU科
  • 收稿日期:2018-12-03 修回日期:2019-02-16 出版日期:2019-04-15 发布日期:2019-05-27
  • 通讯作者: 冯津萍 E-mail:583309443@qq.com
  • 作者简介:郭攀（1993），男，硕士在读，主要从事冠心病与心力衰竭的研究

Research advances on trimethylamine N-oxide of metabolite of gut flora and heart failure

GUO Pan1,2, FENG Jin-ping3△, FENG Chao3, CHEN Shu-tao3   

  1. 1 Thoracic Clinical College, Tianjin Medical University, Tianjin 300222, China; 2 Graduate School of Medicine, Tianjin Medical University; 3 Department of CICU, Tianjin Chest Hospital
  • Received:2018-12-03 Revised:2019-02-16 Published:2019-04-15 Online:2019-05-27

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摘要： 摘要：肠道菌群及其代谢产物与心力衰竭的发生发展有着密不可分的联系。许多研究表明，肠道代谢产物氧化三甲胺促进心力衰竭的发生，并与心力衰竭的预后密切相关。本文将主要从氧化三甲胺的致心力衰竭病理生理学机制、临床相关研究及基于此的治疗策略等方面进行综述。

关键词: 心力衰竭, 肠道菌群, 氧化三甲胺

Abstract: Intestinal flora and its metabolites are inextricably associated with the development of heart failure (HF)."Gut hypothesis in HF" indicates that patients with cardiovascular diseases encounter gut flora imbalance and bacterial translocation, which can trigger systemic inflammatory response and eventually promote the progression of heart failure. Studies showed that a higher concentration of trimethylamine N-oxide (TMAO), a kind of intestinal metabolites, could induce the occurrence of cardiovascular adverse events through a variety of mechanisms (such as intensifying myocardial fibrosis, ventricular remodeling and progress of coronary plaque, aggravating water-sodium retention and systemic inflammatory response), and which is closely related to the survival and prognosis of patients with HF. These patients could benefit from the reducing TMAO. This article reviews the research advances of the relationship between intestinal flora or TMAO and heart failure.

Key words: heart failure, intestinal flora, trimethylamine N-oxide