天津医药

天津医药 ›› 2019, Vol. 47 ›› Issue (4): 436-439.doi: 10.11958/20181496

• 综述 • 上一篇    下一篇

雌激素受体与抑郁症的相关性研究进展

穆道周 1，胡桂芳 2，陈雷 3，张彤 4△   

  1. 1山东省济宁市第一人民医院针灸科（邮编272011），2康复医学科；3山东省邹城市兖矿集团总医院精神康复一科；4山东中医 药大学附属医院针灸科
  • 收稿日期:2018-10-08 修回日期:2019-01-15 出版日期:2019-04-15 发布日期:2019-05-27
  • 通讯作者: 张彤 E-mail:zhangtongzhongyi@sohu.com
  • 作者简介:穆道周（1976），女，博士，主治医师，主要从事中西医结合治疗情志病的研究

Recent research progress of the relationship between estrogen receptor and depression

MU Dao-zhou1, HU Gui-fang2, CHEN Lei3, ZHANG Tong4△   

  1. 1 Department of Acupuncture and Moxibustion, 2 Department of Rehabilitation Medicine, Jining First People’s Hospital, Jining 272011, China; 3 the First Department of Mental Rehabilitation, Yankuang Group General Hospital; 4 Department of Acupuncture and Moxibustion, the Affiliated Hospital of Shandong University of Traditional Chinese Medicine
  • Received:2018-10-08 Revised:2019-01-15 Published:2019-04-15 Online:2019-05-27

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摘要： 雌激素主要通过雌激素受体发挥抗抑郁作用。目前研究较多的是雌激素受体 α（ERα）、雌激素受体 β （ERβ）和 G蛋白偶联雌激素受体（GPER）。三者在雌激素的抗抑郁作用中发挥不同的效应，其中 GPER可能与雌激 素的快速抗抑郁作用有关。深入了解雌激素受体的不同效应对于寻找治疗抑郁症的新靶点，充分发挥雌激素的抗 抑郁作用，最大程度减少其不良反应具有重要意义。

关键词: 受体, 雌激素, 雌激素受体α, 雌激素受体β, 抑郁症, 综述, G蛋白偶联雌激素受体

Abstract: Estrogen exerts antidepressant effects mainly through estrogen receptors. Presently, estrogen receptor α (ERα), estrogen receptor β (ERβ) and G-protein coupled estrogen receptor (GPER) have been studied a lot. The three kinds of estrogen receptors play different roles in the antidepressant effects, and GPER may be related to the rapid antidepressant effects of estrogen. It is important to fully understand the different effects of estrogen receptors in order to find new targets for the treatment of depression, fully play the antidepressant effects of estrogen and reduce side effects.

Key words: receptors, estrogen, estrogen receptor α, estrogen receptor β, depressive disorder, review, G-protein coupled estrogen receptor