天津医药

天津医药 ›› 2020, Vol. 48 ›› Issue (11): 1125-1130.doi: 10.11958/20201796

• 综述 • 上一篇    下一篇

高迁移率族蛋白1在心肌缺血再灌注损伤中作用的研究进展

陈川斌，黄锋△   

  1. 广西医科大学第一附属医院心血管内科（邮编530021）
  • 收稿日期:2020-06-28 修回日期:2020-08-09 出版日期:2020-11-15 发布日期:2020-11-15

Research progress on the role of high mobility group box-1 in myocardial ischemia reperfusion injury

CHEN Chuan-bin, HUANG Feng△   

  1. Department of Cardiology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China;
  • Received:2020-06-28 Revised:2020-08-09 Published:2020-11-15 Online:2020-11-15

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摘要： 心肌缺血再灌注损伤的发病机制复杂。高迁移率族蛋白1（high mobility group box-1，HMGB1）在心肌缺血再灌注损伤中扮演重要角色，参与炎症反应、细胞凋亡和自噬等过程，成为防治心肌缺血再灌注损伤的潜在干预靶点。本文就HMGB1在心肌缺血再灌注损伤中的作用机制作一综述。

关键词: HMGB1蛋白质, 心肌再灌注损伤, 细胞凋亡, 自噬, 炎症反应

Abstract: The pathogenesis of myocardial ischemia reperfusion injury is complex. Recent studies have shown that high mobility group box-1 (HMGB1) plays an important role in myocardial ischemia reperfusion injury and is involved in inflammatory response, apoptosis, autophagy and other processes, which has become a potential intervention target for prevention and treatment of myocardial ischemia reperfusion injury. Therefore, this paper reviews the mechanism of HMGB1 in myocardial ischemia reperfusion injury.

Key words: HMGB1 protein, myocardial reperfusion injury, apoptosis, autophagy, inflammatory response