天津医药

天津医药 ›› 2020, Vol. 48 ›› Issue (7): 670-676.doi: 10.11958/20192852

• 综述 • 上一篇    下一篇

STAT5与肿瘤关系的研究进展

赵玉，张俊伶，冯国兴，樊赛军△   

  1. 中国医学科学院北京协和医学院放射医学研究所，天津市放射医学与分子核医学重点实验室（邮编 300192）
  • 收稿日期:2019-09-16 修回日期:2020-04-24 出版日期:2020-07-15 发布日期:2020-07-16
  • 作者简介:赵玉（1994），女，博士在读，主要从事辐射防护药物的研究

Research progress on the role of STAT5 in tumors

ZHAO Yu, ZHANG Jun-ling, FENG Guo-xing, FAN Sai-jun△   

  1. Institute of Radiation Medicine, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Tianjin 300192, China
  • Received:2019-09-16 Revised:2020-04-24 Published:2020-07-15 Online:2020-07-16

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摘要：

信号转导和转录激活因子（STAT）5是STAT家族中的成员，其有STAT5A和STAT5B两个高度同源的亚型。STAT5广泛参与细胞增殖、分化、凋亡、衰老、造血和免疫等多种生物学过程。STAT5失调与白血病、乳腺癌、前列腺癌、黑色素瘤、甲状腺癌等多种恶性肿瘤的发生发展密切相关，且影响肿瘤的放疗、化疗效果以及患者预后。STAT5 可作为肿瘤治疗的重要靶点，靶向STAT5可增强前列腺癌、头颈癌等多种肿瘤的放疗敏感性，为肿瘤治疗提供了新的策略。本文就STAT5对肿瘤发生发展的影响、STAT5的靶向治疗策略进行综述。

关键词: STAT5转录因子, 肿瘤, 分子靶向治疗, 放射疗法, STAT5A, STAT5B, 综述

Abstract: Signal transducer and activator of transcription 5 (STAT5) is a member of signal transducer and activator of transcription family, which has two highly homologous subtypes: STAT5A and STAT5B. STAT5 is widely involved in various biological processes such as cell proliferation, differentiation, apoptosis, senescence, hematopoiesis and immunity. The dysregulation of STAT5 is closely related to the occurrence and development of malignant tumors such as leukemia, breast cancer, prostate cancer, melanoma and thyroid cancer. STAT5 can also affect tumor radiotherapy and chemotherapy as well as prognosis of patients. Nowadays, STAT5 has become a key target for cancer treatment. Targeting STAT5 could increase the radiosensitivity of prostate cancer, head and neck cancer and other tumors, which provided a new strategy for tumor treatment. This article reviews the role of STAT5 in several malignant tumors and strategies of targeting STAT5.

Key words: STAT5 transcription factor, neoplasms, molecular targeted therapy, radiotherapy, STAT5A, STAT5B; review