天津医药 ›› 2023, Vol. 51 ›› Issue (7): 751-755.doi: 10.11958/20222046

• 临床研究 • 上一篇    下一篇

伴血脂异常的儿童IgA血管炎肾炎尿蛋白和病理特征分析

白梦刻1,2(), 杨晓青1,2, 梅晓峰1,2, 李金刚1,2, 张秋爽1,2, 黄岩杰1,2,()   

  1. 1 河南中医药大学第-附属医院儿科(邮编450000)
    2 河南中医药大学儿科医学院
  • 收稿日期:2022-12-09 修回日期:2023-02-10 出版日期:2023-07-15 发布日期:2023-07-18
  • 通讯作者: 黄岩杰 E-mail:huangyanjie69@163.com
  • 作者简介:白梦刻( 1995),男,主管检验技师,主要从事小儿肾脏疾病生物标志物方面研究。E-mail:bmk92121@163.com
  • 基金资助:
    国家自然科学基金面上项目(82174187);河南省中医药学科领军人才项目(豫卫中医函[2021]8号);河南省特色骨干学科中医学学科建设项目(STG-ZYXKY-2020008)

Analysis of the urinary protein and pathological characteristics of IgA vasculitis with nephritis in children with dyslipidemia

BAI Mengke1,2(), YANG Xiaoqing1,2, MEI Xiaofeng1,2, LI Jin’gang1,2, ZHANG Qiushuang1,2, HUANG Yanjie1,2,()   

  1. 1 Department of Pediatrics, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China
    2 College of Pediatrics, Henan University of Traditional Chinese Medicine
  • Received:2022-12-09 Revised:2023-02-10 Published:2023-07-15 Online:2023-07-18
  • Contact: HUANG Yanjie E-mail:huangyanjie69@163.com

摘要:

目的 探讨血脂异常对IgA血管炎肾炎(IgAVN)患儿尿蛋白及病理特征的影响。方法 选取经临床和病理诊断为IgAVN的患儿316例。将IgAVN患儿按照血脂情况分为血脂正常组(121例)和血脂异常组(195例),再将血脂异常组分为高胆固醇血症组(55例)、高甘油三酯血症组(44例)、混合性高脂血症组(58例)及低高密度脂蛋白胆固醇(HDL-C)血症组(38例)4个亚组。收集患儿的性别、年龄、24 h尿蛋白定量(24 hUP)、尿蛋白/肌酐(UPCR)、尿免疫球蛋白G/肌酐(UIgG/Cr)、尿视黄醇结合蛋白/肌酐(URBP/Cr)、尿红细胞计数(URBC)、血清白蛋白、总胆固醇(TC)、三酰甘油(TG)、HDL-C;按照国际儿童肾脏病研究协作组的IgAVN分级标准对肾脏病理分级;参照IgA肾病(IgAN)牛津病理分型对患儿进行半定量评分;比较血脂正常组与血脂异常组、各亚组的临床资料和病理特征。结果 血脂异常组血清白蛋白水平下降,24 hUP、UPCR、UIgG/Cr、URBP/Cr水平及血清白蛋白<30 g/L的患儿占比高于血脂正常组(P<0.05);患儿病理分级主要以Ⅲ级(223例,70.6%)和Ⅱ级(82例,25.6%)为主,其中Ⅳ级(11例,3.8%)患儿全部在血脂异常组;血脂异常组病理分级Ⅲ级+Ⅳ级、弥漫性系膜增生(Mb)、肾小球节段性硬化或粘连(S1)占比高于血脂正常组(P<0.05);与血脂正常组相比,高胆固醇血症组URBP/Cr升高,血清白蛋白降低,混合性高脂血症组24 hUP、UPCR、UIgG/Cr、URBP/Cr、URBC升高,血清白蛋白降低(P<0.05);高胆固醇血症组和混合性高脂血症组的病理分级Ⅲ级+Ⅳ级、Mb和S1占比高于血脂正常组(P<0.05)。结论 伴高胆固醇血症、混合性高脂血症的IgAVN患儿肾脏病理损伤和蛋白尿程度较血脂正常患儿严重,应积极降脂治疗。

关键词: 血管炎, 肾炎, 免疫球蛋白A, 血脂异常, 蛋白尿, 病理特征

Abstract:

Objective To investigate the effect of dyslipidemia on urinary protein and pathological characteristics in children with immunoglobulin vasculitis with nephritis (IgAVN). Methods A total of 316 children with IgAVN diagnosed clinically and pathologically were selected. Children with IgAVN were divided into the normal lipid group (121 cases) and the dyslipidemia group (195 cases) according to the condition of blood lipid. The dyslipidemia group was further divided into the hypercholesterolemia group (55 cases), the hypertriglyceridemia group (44 cases), the mixed hyperlipidemia group (58 cases) and the low high density lipoprotein cholesterol (HDL-C) group(38 cases). The children's sex, age, 24-hour urinary protein quantification (24 hUP), urinary protein/creatinine (UPCR), urinary immunoglobulin G/creatinine (UIgG/Cr), urinary retinol-binding protein/creatinine (URBP/Cr), urinary red blood cell count (URBC), serum albumin, total cholesterol (TC), triacylglycerol (TG) and HDL-C were collected. The renal pathology was graded according to the IgAVN grading standard of the International Study of Kidney Disease in Children. According to the Oxford pathological classification of IgA nephropathy (IgAN), children were scored semi-quantitatively. Clinical data and pathological characteristics of the normal and abnormal blood lipid groups and each subgroup were compared. Results The serum albumin level decreased in the dyslipidemia group, and the proportion of children with 24 h UP, UPCR, UIgG/Cr, URBP/Cr levels, and serum albumin<30 g/L were higher than those in the normal lipid group (P<0.05). The pathological grading of children was mainly grade Ⅲ (223 cases, 70.6%) and grade Ⅱ (82 cases, 25.6%), of which children with grade Ⅳ (11 cases, 3.8%) were all in the dyslipidemia group. The proportion of pathological grade Ⅲ+Ⅳ, diffuse mesangial hyperplasia (Mb), glomerular segmental sclerosis or adhesion (S1) was higher in the dyslipidemia group than that in the normal blood lipid group (P<0.05). Compared with the normal blood lipid group, URBP/Cr increased and serum albumin decreased in the hypercholesterolemia group, while 24 h UP, UPCR, UIgG/Cr, URBP/Cr, URBC increased and serum albumin decreased in the mixed hyperlipidemia group (P<0.05). The proportion of pathological grade Ⅲ+Ⅳ, Mb and S1 was increased in the hypercholesterolemia group and the combined hyperlipidemia group (P<0.05). Conclusion IgAVN children with hypercholesterolemia and mixed hyperlipidemia, whose renal pathological damage and proteinuria are more serious than those with normal blood lipids, should be actively treated with lipid-lowering therapy.

Key words: vasculitis, nephritis, immunoglobulin A, dyslipidemias, proteinuria, pathological features

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