口腔种植修复患者血清CTHRC1、CX3CL1水平与预后的相关性研究

doi:10.11958/20240714

摘要/Abstract

摘要：

目的探究口腔种植修复术患者血清胶原三螺旋重复蛋白-1（CTHRC1）、C-X3-C趋化因子配体1（CX3CL1）水平及其与预后的相关性。方法选择接受口腔种植修复术的患者247例为种植修复组，另择同期健康体检者247例为对照组，采用酶联免疫吸附试验（ELISA）分别测定2组术前1周、术后1周、术后1个月血清CTHRC1、CX3CL1水平。根据患者术后6个月时X线检查结果分为预后不良组（28例）和预后良好组（219例），比较患者术后1个月C反应蛋白（CRP）、白细胞介素6（IL-6）、CTHRC1和CX3CL1。采用多因素Cox回归分析口腔种植修复术患者预后不良的影响因素。结果与对照组相比，种植修复组术前1周时血清CTHRC1、CX3CL1水平无明显变化（P>0.05），术后1周及术后1个月时血清CTHRC1、CX3CL1水平升高（P<0.05）。种植修复组患者术前1周、术后1周、术后1个月血清CTHRC1、CX3CL1水平呈先升高后降低，术后1周时达到最高，分别为（426.85±73.52）μg/L和（142.41±15.26）ng/L。口腔种植修复患者术后1个月CTHRC1与CX3CL1呈正相关（r=0.436，P<0.001）。预后不良组患者CRP、IL-6、CTHRC1和CX3CL1水平高于预后良好组（P<0.05）。多因素Cox回归分析显示，CTHRC1和CX3CL1水平升高是口腔种植修复术患者预后不良的独立危险因素（P<0.05）。结论口腔种植修复术预后不良患者血清CTHRC1和CX3CL1水平升高，两者均为患者预后的独立影响因素。

关键词: 预后, 口腔种植修复术, 胶原三螺旋重复蛋白-1, C-X3-C趋化因子配体1

Abstract:

Objective To investigate seserum levels of collagen triple helix repeat containing protein-1 (CTHRC1) and C-X3-C motif chemokine ligand 1 (CX3CL1) and their correlation with prognosis in patients undergoing oral implant restorations. Methods A total of 247 patients underwent oral implant restorations were selected as the implant restoration group, and 247 healthy subjects who underwent medical checkups during the same period were selected as the control group. Serum CTHRC1 and CX3CL1 levels were detected by enzyme-linked immunosorbent assay (ELISA) at 1 week preoperatively, 1 week postoperatively and 1 month postoperatively in the 2 groups. According to the X-ray examination results of the patients at 6 month after surgery, patients were separated into the poor prognosis group (28 cases) and the good prognosis group (219 cases). C-reactive protein (CRP), interleukin 6 (IL-6), CTHRC1 and CX3CL1 levels were compared in patients at 1 month postoperatively. Multifactor COX regression was applied to analyze factors influencing poor prognosis of implants. Results Compared with the control group, there were no significant changes in serum CTHRC1 and CX3CL1 levels in the implant restoration group at 1 week preoperatively (P>0.05), and serum CTHRC1 and CX3CL1 levels were elevated at 1 week postoperatively and at 1 month postoperatively (P<0.05). The serum levels of CTHRC1 and CX3CL1 showed a trend of first increasing and then decreasing one week before surgery, one week after surgery and one month after surgery in the implant repair group. One week after surgery reached the highest (426.85±73.52) μg/L and (142.41±15.26 ) ng/L, respectively. There was a positive correlation between CTHRC1 and CX3CL1 in patients with oral implant restoration (r=0.436, P<0.001). The inflammatory factors CRP, IL-6, CTHRC1 and CX3CL1 were obviously higher in the poor prognosis group than those in the good prognosis group (P<0.05). Multifactor COX regression analysis showed that both CTHRC1 and CX3CL1 were independent influencing factors for poor implant prognosis in patients underwent oral implant restorations (P<0.05). Conclusion Serum CTHRC1 and CX3CL1 levels are upregulated in patients with poor prognosis for oral implant restorations, and both are independent influencing factors on patient prognosis.

Key words: prognosis, oral implant repair surgery, collagen triple helix repeat containing protein-1, C-X3-C motif chemokine ligand 1

中图分类号:

R783

图/表 4

参考文献 23

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组别	n	时间点	CTHRC1/（μg/L）	CX3CL1/（ng/L）
对照组	247		137.26±21.15	106.68±11.75
种植修复组	247	术前1周	137.18±23.24	107.47±11.58
		术后1周	426.85±73.52^a	142.41±15.26^a
		术后1个月	232.39±31.65^ab	124.16±13.47^ab
t₁			0.029	0.948
t₂			105.855^＊	42.865^＊
t₃			34.773^＊	20.971^＊
F			2 490.827^＊	409.615^＊

组别	n	时间点	CTHRC1/（μg/L）	CX3CL1/（ng/L）
对照组	247		137.26±21.15	106.68±11.75
种植修复组	247	术前1周	137.18±23.24	107.47±11.58
		术后1周	426.85±73.52^a	142.41±15.26^a
		术后1个月	232.39±31.65^ab	124.16±13.47^ab
t₁			0.029	0.948
t₂			105.855^＊	42.865^＊
t₃			34.773^＊	20.971^＊
F			2 490.827^＊	409.615^＊

组别	n		年龄/ 岁		性别（男/女）	抗生素服用（是/否）		BMI/ （kg/m²）		TC/ （mmol/L）
预后良好组	219		38.84±7.15		107/112	196/23		24.17±2.93		3.62±0.88
预后不良组	28		39.68±9.76		16/12	24/4		24.82±3.58		3.73±0.95
t或χ²			0.437		0.682	0.365		0.937		0.674
组别		TG/ （mmol/L）		HDL-C/ （mmol/L）			LDL-C/ （mmol/L）		CRP/ （mg/L）		IL-6/ （μg/L）
预后良好组		1.56±0.17		1.14±0.17			2.72±0.31		1.96±0.21		0.14±0.02
预后不良组		1.62±0.18		1.08±0.14			2.84±0.36		3.05±0.52		0.27±0.04
t或χ²		1.670		1.967			1.870		11.150^＊		15.210^＊

组别	n		年龄/ 岁		性别（男/女）	抗生素服用（是/否）		BMI/ （kg/m²）		TC/ （mmol/L）
预后良好组	219		38.84±7.15		107/112	196/23		24.17±2.93		3.62±0.88
预后不良组	28		39.68±9.76		16/12	24/4		24.82±3.58		3.73±0.95
t或χ²			0.437		0.682	0.365		0.937		0.674
组别		TG/ （mmol/L）		HDL-C/ （mmol/L）			LDL-C/ （mmol/L）		CRP/ （mg/L）		IL-6/ （μg/L）
预后良好组		1.56±0.17		1.14±0.17			2.72±0.31		1.96±0.21		0.14±0.02
预后不良组		1.62±0.18		1.08±0.14			2.84±0.36		3.05±0.52		0.27±0.04
t或χ²		1.670		1.967			1.870		11.150^＊		15.210^＊

组别	n	CTHRC1/（μg/L）	CX3CL1/（ng/L）
预后良好组	219	215.63±62.65	122.25±26.49
预后不良组	28	363.48±82.18	139.15±20.68
t		9.185^＊	3.252^＊