小胶质细胞在脓毒症相关性脑病中的作用及研究进展

doi:10.11958/20231735

天津医药 ›› 2024, Vol. 52 ›› Issue (5): 557-560.doi: 10.11958/20231735

• 综述 • 上一篇

小胶质细胞在脓毒症相关性脑病中的作用及研究进展

贾西瑞¹(), 刘莉洁²^,^△()

1 东南大学生命科学与技术学院（邮编210096）
2 江苏省重症医学重点实验室，东南大学医学院

收稿日期:2023-11-10 修回日期:2023-11-24 出版日期:2024-05-15 发布日期:2024-05-09
通讯作者: ^△ E-mail：liulijie@seu.edu.cn
作者简介:贾西瑞（1997），女，硕士在读，主要从事小胶质细胞与脓毒症相关性脑病研究。E-mail：1829071233@qq.com
基金资助:
国家自然科学基金资助项目(81970893);国家自然科学基金资助项目(82171541);国家自然科学基金资助项目(81670935);江苏省重症医学重点实验室自主课题(JSKLCCM-2022-02-002)

The role and research progress of microglia in sepsis related encephalopathy

JIA Xirui¹(), LIU Lijie²^,^△()

1 Department of Biology, School of Life Science and Technology, Southeast University, Nanjing 210096, China
2 Department of Physiology, Jiangsu Provincial Key Laboratory of Critical Care Medicine, School of Medicine, Southeast University

Received:2023-11-10 Revised:2023-11-24 Published:2024-05-15 Online:2024-05-09
Contact: ^△ E-mail：liulijie@seu.edu.cn

贾西瑞, 刘莉洁. 小胶质细胞在脓毒症相关性脑病中的作用及研究进展[J]. 天津医药, 2024, 52(5): 557-560.

JIA Xirui, LIU Lijie. The role and research progress of microglia in sepsis related encephalopathy[J]. Tianjin Medical Journal, 2024, 52(5): 557-560.

摘要/Abstract

摘要：

脓毒症相关性脑病（SAE）是脓毒症患者常见并发症，以脑功能障碍为主要特征，且相当比例的患者存在长期认知功能障碍。中枢神经系统是较早受到脓毒症引起的外周炎症影响的区域之一。小胶质细胞作为中枢神经系统常驻免疫细胞，可协调脑内炎症反应，在脑的固有免疫和适应性免疫应答中扮演重要角色，在SAE发生发展中起关键作用。就小胶质细胞功能表型及其在SAE中的作用进行综述以探讨小胶质细胞在SAE防治中的潜在价值。

关键词: 脓毒症, 小神经胶质细胞, 脓毒症相关性脑病, 突触, 神经炎症

Abstract:

Sepsis associated encephalopathy (SAE) is a common complication in patients with sepsis. It is characterized by brain dysfunction, and a considerable proportion of patients have long-term cognitive impairment. The central nervous system is one of earliest regions affected by peripheral inflammation caused by sepsis. As resident immune cells of central nervous system, microglia can coordinate inflammatory responses in brain and play an important role in the innate and adaptive immune responses of brain. Therefore, it plays a crucial role in the occurrence and development of SAE. In this paper, the functional phenotypes of microglia and their role in SAE are reviewed to explore the potential value of microglia in the prevention and treatment of SAE.

Key words: sepsis, microglia, sepsis related encephalopathy, synapses, neuroinflammation

中图分类号:

R631

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小胶质细胞在脓毒症相关性脑病中的作用及研究进展

The role and research progress of microglia in sepsis related encephalopathy

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