天津医药

天津医药 ›› 2018, Vol. 46 ›› Issue (4): 440-443.doi: 10.11958/20170884

• 综述 • 上一篇    下一篇

长链非编码RNA在骨关节炎中调控机制的研究进展

肖瑜，刘军△   

  1. 作者单位：天津市天津医院关节外科（邮编300211） 作者简介：肖瑜（1978），男，博士，副主任医师，主要从事骨关节炎基础与临床研究 △通讯作者 E-mail：drliujun@hotmail.com
  • 收稿日期:2017-08-10 修回日期:2018-02-06 出版日期:2018-04-15 发布日期:2018-04-15
  • 通讯作者: 肖瑜 E-mail:xm9702023@163.com

Research progress on the regulation mechanism of long chain noncoding RNA in osteoarthritis

XIAO Yu, LIU Jun△   

  1. Department of Joint Surgery, Tianjin Hospital, Tianjin 300211, China △Corresponding Author E-mail：drliujun@hotmail.com
  • Received:2017-08-10 Revised:2018-02-06 Published:2018-04-15 Online:2018-04-15

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摘要： 摘要：随着社会人口老龄化，骨关节炎（OA）的发病率越来越高，常导致关节疼痛，运动受限，关节软骨组织炎症 和逐步退化。目前常规治疗的临床效果并不理想，最终往往需要通过手术解决。近年来研究发现，长链非编码RNA （lncRNA）参与了OA发病的各种机制，包括炎性因素、机械因素和细胞凋亡等，而且每种调控过程都有特定的微小 RNA（miRNA）介导。因此，针对差异性 lncRNA 的靶基因治疗研究也越来越深入，希望能够找到治疗 OA 的有效 方法。

关键词: 骨关节炎, 基因表达调控, 炎症, 细胞凋亡, 综述, 长链非编码RNA

Abstract: Abstract: With the aging of the population, the incidence of osteoarthritis (OA) is increasing, and which often leads joint pain, limited movement, articular cartilage tissue inflammation and progressive degeneration. At present, the clinical ef⁃ fect of conventional therapy is not ideal, and it is often needed to be solved by surgery. In recent years, long chain noncoding RNA (lncRNA) has been found to be involved in a variety of mechanisms in the pathogenesis of OA, including inflammatory factors, mechanical factors and cell apoptosis. And specific micro RNA (miRNA) mediates the regulation of each process. Therefore, the study of target gene therapy for differentiated lncRNA is becoming more and more in-depth, hoping to find an effective method for human OA treatment.

Key words: osteoarthritis, gene expression regulation, inflammation, apoptosis, review, long noncoding RNA