天津医药

天津医药 ›› 2019, Vol. 47 ›› Issue (4): 431-435.doi: 10.11958/20182109

• 综述 • 上一篇    下一篇

CREB在血管新生、抗凋亡以及肺癌中的研究进展

刘肖，段勇，张艳亮   

  1. 云南省检验医学重点实验室，昆明医科大学第一附属医院医学检验科，云南省实验诊断研究所（邮编 650032）
  • 收稿日期:2018-12-21 修回日期:2019-01-15 出版日期:2019-04-15 发布日期:2019-05-27
  • 通讯作者: 刘肖 E-mail:18088446698@163.com
  • 作者简介:刘肖（1995），女，硕士在读，主要从事临床生物化学与分子生物学方向的研究
  • 基金资助:
    CREB3L4基因在云南宣威肺癌中的表达及作用机制研究;CREB3L4在云南宣威肺癌发病中的作用及分子机制研究

Research progress of CREB in angiogenesis, anti-apoptosis and lung cancer

LIU Xiao, DUAN Yong, ZHANG Yan-liang   

  1. Yunnan Key Laboratory of Laboratory Medicine, Department of Clinical Laboratory, the First Affiliated Hospital of Kunming Medical University, Yunnan Institute of Experimental Diagnosis, Kunming 650032, China
  • Received:2018-12-21 Revised:2019-01-15 Published:2019-04-15 Online:2019-05-27
  • Contact: Xiao Liu E-mail:18088446698@163.com
  • Supported by:
    Expression and Mechanism of CREB3L4 Gene in Xuanwei Lung Cancer in Yunnan Province;The role and molecular mechanism of CREB3L4 in the pathogenesis of lung cancer in Xuanwei, Yunnan

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摘要： cAMP反应元件结合蛋白（CREB）作为一种转录因子在长期记忆形成和多种恶性肿瘤的发生及治疗领域 已被广泛研究，本文就 CREB基因在血管新生、细胞增殖及抗凋亡、与尼古丁致癌过程的关联以及在肿瘤（尤其是肺 癌）中的研究进展进行综述，以期为今后 CREB家族蛋白的研究提供参考。

关键词: cAMP反应元件结合蛋白质, 新生血管化, 病理性, 细胞凋亡, 尼古丁, 肺肿瘤, 癌

Abstract: cAMP-response element binding protein (CREB) has been widely studied as a transcriptional factor in the field of long-term memory formation and the development and treatment of various malignant tumors. This review summarized the research progress of CREB gene in neovascularization, cell proliferation and anti-apoptosis, and the relationship between CREB geen and the carcinogenic process of nicotine and tumors (especially lung cancer) in order to provide references for future research of CREB family proteins.

Key words: cyclic AMP response element-binding protein, neovascularization, pathologic, apoptosis, nicotine, lung neoplasms, carcinoma