天津医药

天津医药 ›› 2020, Vol. 48 ›› Issue (6): 558-562.

• 循证医学 • 上一篇    下一篇

FTO基因rs8050136多态性与多囊卵巢综合征相关性的Meta分析 #br#

薛敏敏，刘丽萍，邹喜娣，杜光辉，王月英，张心怡，付志刚△
  

  1. 中国人民解放军联勤保障部队第九八三医院健康医学科（邮编 300142）
  • 收稿日期:2019-12-03 修回日期:2020-03-11 出版日期:2020-06-15 发布日期:2020-06-15
  • 通讯作者: 薛敏敏 E-mail:xueminmin1@126.com

The association between FTO gene rs8050136 polymorphism and polycystic ovary syndrome: A Meta-analysis

XUE Min-min, LIU Li-ping, ZOU Xi-di, DU Guang-hui, WANG Yue-ying, ZHANG Xin-yi, FU Zhi-gang△ #br#   

  1. Department of Health Sciences, 983 Hospital of Joint Logistics Support Force of PLA, Tianjin 300142, China
  • Received:2019-12-03 Revised:2020-03-11 Published:2020-06-15 Online:2020-06-15
  • Contact: Minmin XUE E-mail:xueminmin1@126.com

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摘要： 摘要：目的 探讨肥胖相关基因（FTO）rs8050136多态位点与多囊卵巢综合征（PCOS）发病的相关性。方法 检索Pubmed/MEDLINE、Embase、Web of Science、中国知网（CNKI）、万方数据库、维普中文期刊及中国生物医学文献数 据库（CBM），检索时间范围为建库到2019年11月11日。按纳入、排除标准选择FTO基因rs8050136 A/C多态性与 PCOS关系的病例对照研究。应用Rev-Man 5.2及STATA 11.2软件进行Meta分析。结果 纳入5篇病例对照研究共 2 750例患者，其中PCOS组1 238例，对照组1 512例。Meta分析结果显示，未发现携带A等位基因者发生PCOS的危 险性高于携带C等位基因者（OR=1.19，95%CI：0.98~1.43，P=0.08）。携带AA基因型的人群发生PCOS的风险是携带 CC基因型人群的1.64倍（95%CI：1.02~2.63，P=0.04），未发现携带AC基因型的人群发生PCOS的风险较CC基因型人 群增高（OR=1.20，95%CI：0.85~1.69，P=0.30）。结论 FTO基因rs8050136多态性与PCOS发病相关。

关键词: 多囊卵巢综合征, 多态现象, 遗传, Meta分析, FTO基因

Abstract: Abstract: Objective To explore the association between the polymorphisms of fat mass and obesity associated gene (FTO) rs8050136 and the risk of polycystic ovary syndrome (PCOS). Methods Pubmed/MEDLINE, Embase, Web of Science, CNKI, Wanfang database, VIP Chinese Journal and CBM were searched. The searching time was from the establishment to November 11, 2019. According to the inclusion and exclusion criteria, case-control studies on the relationship between the FTO gene rs8050136 A/C polymorphism and PCOS were selected. The Rev-Man 5.2 and STATA 11.2 software were used for meta-analysis. Results Five case-control studies were included with a total of 2 750 patients, including 1 238 PCOS patients and 1 512 controls. Meta-analysis showed that the risk of PCOS in people with A allele was not higher than that in people with C allele (OR=1.19, 95% CI: 0.98-1.43, P=0.08). The risk of PCOS in people with AA genotype was 1.64 times higher than that in people with CC genotype (95% CI: 1.02-2.63, P=0.04) and the risk of PCOS in people with AC genotype was not higher than that in people with CC genotype (OR=1.20, 95% CI: 0.85-1.69, P=0.30). Conclusion rs8050136 polymorphism of FTO gene is associated with PCOS.

Key words: polycystic ovary syndrome, polymorphism, genetic, Meta-analysis, FTO gene