天津医药

天津医药 ›› 2021, Vol. 49 ›› Issue (6): 613-616.doi: 10.11958/20210275

• 临床研究 • 上一篇    下一篇

血清白蛋白水平与急性缺血性卒中患者认知功能的相关性

门慧，金香兰，赵世娇，王莹，李施新，周晶
  

  1. 1北京中医药大学第二临床医学院（邮编100029）；2北京中医药大学东方医院脑病二科
  • 收稿日期:2021-01-29 修回日期:2021-03-18 出版日期:2021-06-15 发布日期:2021-06-15
  • 通讯作者: 金香兰 E-mail:jxlan2001@126.com
  • 基金资助:
    全国中医临床特色技术传承骨干人才培训项目;北京中医药大学基本科研业务费重点攻关项目

Correlation between serum albumin level and cognitive impairment after acute ischemic stroke #br#

MEN Hui, JIN Xiang-lan, ZHAO Shi-jiao, WANG Ying, LI Shi-xin, ZHOU Jing   

  1. 1 The Second Clinical Medical College of Beijing University of Chinese Medicine, Beijing 100029, China; 2 Department Ⅱ of
    Encephalopathy, Dongfang Hospital, Beijing University of Chinese Medicine
  • Received:2021-01-29 Revised:2021-03-18 Published:2021-06-15 Online:2021-06-15

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摘要： 目的 探讨血清白蛋白水平与急性缺血性卒中（AIS）患者认知功能的相关性，为卒中后认知障碍的早期 识别提供依据。方法 选取AIS患者103例，经简易智力状态检查量表（MMSE）测评分为认知障碍组（MMSE评分≤ 26分，48例）和无认知障碍组（MMSE评分＞26分，55例）。比较2组患者人口学特征、入院时血清生化指标及影像学 特征的差异，多因素Logistic回归分析AIS患者认知功能障碍的影响因素，采用Spearman相关分析白蛋白水平与患者 MMSE评分的相关性。结果 与无认知障碍组比较，认知障碍组患者年龄大，受教育程度偏低，低白蛋白（≤40 g/L）患 者所占比例升高（52.08% vs. 18.18%）。多因素Logistic回归分析显示低白蛋白（OR=3.379，95%CI：1.227~9.302，P＜ 0.05）是AIS患者发生认知障碍的危险因素。MMSE评分与血清白蛋白水平呈正相关（rs=0.426，P＜0.01）。结论 低 白蛋白水平是AIS患者认知功能下降的危险因素之一，早期进行认知评估，有助于卒中后认知障碍的早期识别。

关键词: 卒中, 认知障碍, 血清白蛋白, 危险因素, 简易智力状态检查量表

Abstract: Objective To investigate the correlation between serum albumin level and cognitive function in patients with acute ischemic stroke (AIS) and to provide a basis for the early identification of cognitive impairment after stroke. Methods A total of 103 AIS patients were selected and divided into cognitive impairment group (MMSE≤26, n=48) and the group without cognitive impairment (MMSE>26, n=55) by Mini-Mental State Examination (MMSE). The differences in demographic characteristics, serum biochemical parameters and imaging characteristics at admission were compared between the 2 groups. The multivariate logistic regression was used to analyze the influencing factors of cognitive dysfunction in AIS patients, and Spearman correlation was used to analyze the correlation between albumin levels and MMSE scores in patients. Results Compared with the group without cognitive impairment, patients in the cognitive impairment group were older, had a lower education level and had an increased proportion of low albumin (≤ 40 g/L) level (52.08% vs. 18.18%). Multivariate logistic regression analysis showed that the low albumin was one of risk factors for cognitive impairment in AIS patients (OR=3.379, 95%CI: 1.227-9.302, P＜0.05). There was a positive correlation between MMSE score and the serum albumin level (rs=0.426, P＜0.01). Conclusion The low albumin level is one of risk factors for cognitive decline in patients with AIS. The early cognitive assessment is helpful for early recognition of cognitive impairment after stroke.

Key words: stroke, cognition disorders, serum albumin, risk factors, mini-mental state examination