间充质干细胞介导线粒体转移机制及其在癌症治疗中的应用进展

doi:10.11958/20220498

天津医药 ›› 2022, Vol. 50 ›› Issue (11): 1217-1221.doi: 10.11958/20220498

间充质干细胞介导线粒体转移机制及其在癌症治疗中的应用进展

孙文梅(), 王家平^△(), 张维护, 肖佩林

昆明医科大学第二附属医院放射科（邮编650101）

收稿日期:2022-04-02 修回日期:2022-05-06 出版日期:2022-11-15 发布日期:2022-11-11
通讯作者: 王家平 E-mail:swmkmmu@163.com;jiapingwang12@163.com
作者简介:孙文梅（1997），女，硕士在读，主要从事干细胞治疗及腹部影像方面研究。E-mail：swmkmmu@163.com
基金资助:
国家自然科学基金资助项目(81860144)

Research progress related to the mechanism of mesenchymal stem cell-mediated mitochondrial transfer and its application in cancer treatment

SUN Wenmei(), WANG Jiaping^△(), ZHANG Weihu, XIAO Peilin

Department of Radiology, the Second Affiliated Hospital of Kunming Medical University, Kunming 650101, China

Received:2022-04-02 Revised:2022-05-06 Published:2022-11-15 Online:2022-11-11
Contact: WANG Jiaping E-mail:swmkmmu@163.com;jiapingwang12@163.com

孙文梅, 王家平, 张维护, 肖佩林. 间充质干细胞介导线粒体转移机制及其在癌症治疗中的应用进展[J]. 天津医药, 2022, 50(11): 1217-1221.

SUN Wenmei, WANG Jiaping, ZHANG Weihu, XIAO Peilin. Research progress related to the mechanism of mesenchymal stem cell-mediated mitochondrial transfer and its application in cancer treatment[J]. Tianjin Medical Journal, 2022, 50(11): 1217-1221.

摘要/Abstract

摘要：

含有间充质干细胞的肿瘤微环境在癌细胞增殖、耐药和转移过程中起到了关键作用。间充质干细胞介导线粒体转移至癌细胞，增强线粒体的氧化磷酸化，促进癌症进展。干扰线粒体转移的相关因素对癌症治疗产生积极影响。该文就间充质干细胞介导线粒体转移及其在癌症治疗中的相关应用进行阐述，旨在为癌症治疗提供新的策略和思路。

关键词: 线粒体, 间充质基质细胞, 干细胞, 氧化磷酸化, 肿瘤, 纳米管, 微管

Abstract:

The tumor microenvironment that contains mesenchymal stem cells (MSCs) plays a significant role in cancer recurrence, drug resistance and metastasis. MSCs can transfer their own mitochondria to tumor cells, enhance mitochondrial oxidative phosphorylation and promote cancer progression. Factors that interfere with mitochondrial transfer have positive effects on cancer. This paper elaborates on the mechanisms associated with the mitochondrial transfer and its related application in cancer treatment, aiming to provide novel strategies and ideas for cancer treatment.

Key words: mitochondria, mesenchymal stromal cells, stem cells, oxidative phosphorylation, neoplasms, nanotubes, microtubules

中图分类号:

R730

图/表 1

参考文献 42

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间充质干细胞介导线粒体转移机制及其在癌症治疗中的应用进展

Research progress related to the mechanism of mesenchymal stem cell-mediated mitochondrial transfer and its application in cancer treatment

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