高脂饮食与认知障碍关系的研究进展

doi:10.11958/20221298

天津医药 ›› 2023, Vol. 51 ›› Issue (4): 441-444.doi: 10.11958/20221298

高脂饮食与认知障碍关系的研究进展

李晓晓¹(), 白艳杰²^,^*(), 王岩¹, 张雍闯¹, 陈丽敏¹, 陈淑颖¹

1 河南中医药大学（邮编450046）
2 河南中医药大学第一附属医院

收稿日期:2022-08-19 修回日期:2022-11-21 出版日期:2023-04-15 发布日期:2023-04-20
通讯作者: 白艳杰 E-mail:1173987953@qq.com;baiyj66@126.com
作者简介:李晓晓（1998），女，硕士在读，主要从事脑卒中后认知障碍康复方面研究。E-mail：1173987953@qq.com
基金资助:
国家重点研发计划(2018YFC1706004);河南省中医药科学研究专项重点课题(20-21ZY1009);河南省中医药传承与创新人才工程（仲景工程）中医药学科拔尖人才(CZ0237-08);河南省卫生健康委国家中医临床研究基地科研专项重点项目(2022JDZX005)

Research progress on the relationship between high fat diet and cognitive impairment

LI Xiaoxiao¹(), BAI Yanjie²^,^*(), WANG Yan¹, ZHANG Yongchuang¹, CHEN Limin¹, CHEN Shuying¹

1 Henan University of Chinese Medicine, Zhengzhou 450046, China
2 The First Affiliated Hospital of Henan University of Chinese Medicine

Received:2022-08-19 Revised:2022-11-21 Published:2023-04-15 Online:2023-04-20
Contact: BAI Yanjie E-mail:1173987953@qq.com;baiyj66@126.com

李晓晓, 白艳杰, 王岩, 张雍闯, 陈丽敏, 陈淑颖. 高脂饮食与认知障碍关系的研究进展[J]. 天津医药, 2023, 51(4): 441-444.

LI Xiaoxiao, BAI Yanjie, WANG Yan, ZHANG Yongchuang, CHEN Limin, CHEN Shuying. Research progress on the relationship between high fat diet and cognitive impairment[J]. Tianjin Medical Journal, 2023, 51(4): 441-444.

摘要/Abstract

摘要：

认知障碍是指感觉、学习记忆、言语、注意和执行等一个或多个方面出现障碍，严重影响患者的生活质量。高脂饮食可造成神经元损伤和脑血管功能障碍，从而引起认知障碍。就高脂饮食诱导认知障碍的相关机制和治疗进展进行综述，以期为有效预防和治疗认知障碍提供新的思路。

关键词: 认知障碍, 膳食，高脂, 神经炎, 胰岛素抵抗, 突触, 氧化性应激

Abstract:

Cognitive impairment refers to one or more impairments in feeling, learning and memory, speech, attention and execution, which seriously affects the quality of life of patients. Studies have shown that high fat diet (HFD) can cause neuronal damage and cerebrovascular dysfunction, thus causing cognitive impairment. This article reviews the relevant mechanisms and treatment progress of HFD induced cognitive impairment, with a view to providing new ideas for effective prevention and treatment of cognitive impairment.

Key words: cognition disorders, diet, high-fat, neuritis, insulin resistance, synapses, oxidative stress

中图分类号:

R743

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高脂饮食与认知障碍关系的研究进展

Research progress on the relationship between high fat diet and cognitive impairment

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