HMGB1和RAGE在呼吸机相关性肺炎中作用的研究进展

doi:10.11958/20230486

天津医药 ›› 2023, Vol. 51 ›› Issue (11): 1276-1280.doi: 10.11958/20230486

• 综述 • 上一篇

HMGB1和RAGE在呼吸机相关性肺炎中作用的研究进展

黄绚丽(), 秘乐, 徐宇, 王红嫚^△()

遵义医科大学第五附属（珠海）医院呼吸与危重症医学科（邮编519100）

收稿日期:2023-04-17 修回日期:2023-07-03 出版日期:2023-11-15 发布日期:2023-11-07
通讯作者: ^△E-mail：2496453591@qq.com
作者简介:黄绚丽（1996），女，硕士在读，主要从事呼吸危重症急救方面研究。E-mail：huang_xuanli2021@126.com
基金资助:
国家自然科学基金资助项目(81960023)

Research progress on the role of HMGB1 and RAGE in ventilator associated pneumonia

HUANG Xuanli(), MI Le, XU Yu, WANG Hongman^△()

Department of Respiratory and Critical Care Medicine, the Fifth Affiliated (Zhuhai) Hospital of Zunyi Medical University, Zhuhai 519100, China

Received:2023-04-17 Revised:2023-07-03 Published:2023-11-15 Online:2023-11-07
Contact: ^△E-mail：2496453591@qq.com

黄绚丽, 秘乐, 徐宇, 王红嫚. HMGB1和RAGE在呼吸机相关性肺炎中作用的研究进展[J]. 天津医药, 2023, 51(11): 1276-1280.

HUANG Xuanli, MI Le, XU Yu, WANG Hongman. Research progress on the role of HMGB1 and RAGE in ventilator associated pneumonia[J]. Tianjin Medical Journal, 2023, 51(11): 1276-1280.

摘要/Abstract

摘要：

呼吸机相关性肺炎（VAP）发病机制复杂，炎症反应在VAP的病理进程中具有关键作用。高迁移率族蛋白B1（HMGB1）和晚期糖基化终末产物受体（RAGE）是促发炎症反应的关键介质，且在脓毒症的进程中发挥着重要的作用；而脓毒症是VAP的主要结局及死因。二者可能作为早期发现VAP进展为脓毒症的标志物及治疗靶点。就HMGB1/RAGE在VAP炎症发展中的作用及相关治疗进展进行综述。

Abstract:

The pathogenesis of ventilator associated pneumonia (VAP) is complicated, and inflammatory response plays a key role in the pathological process of VAP. High mobility group protein B1 (HMGB1) and advanced glycation end-product receptor (RAGE) are key mediums for inflammatory response and play an important role in the progression of sepsis. Sepsis is the main outcome and cause of death of VAP. Therefore, HMGB1/RAGE may be used as markers and therapeutic targets for early detection of VAP progression into sepsis. This article reviews the role of HMGB1/RAGE in the development of VAP inflammatory and the progress in its treatment.

Key words: pneumonia, ventilator-associated, HMGB1 protein, receptor for advanced glycation end products, sepsis, inflammation, inhibitors

中图分类号:

R563.1

参考文献 37

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HMGB1和RAGE在呼吸机相关性肺炎中作用的研究进展

Research progress on the role of HMGB1 and RAGE in ventilator associated pneumonia

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