天津医药

天津医药 ›› 2022, Vol. 50 ›› Issue (6): 668-672.doi: 10.11958/20212621

• 综述 • 上一篇    

C-藻蓝蛋白对肝脏损伤的保护作用及机制研究进展

吕康宁1，2，王蕾2，秦松2，王莉3△   

  1. 1烟台大学海洋学院（邮编264003）；2中国科学院烟台海岸带研究所；3烟台市奇山医院
  • 收稿日期:2021-11-24 修回日期:2022-01-19 出版日期:2022-06-15 发布日期:2023-12-20
  • 通讯作者: 王莉 E-mail:liliwang2200@163.com
  • 基金资助:
    国家重点研发项目（2018YFD0901102）；烟台市重点研发项目（2020MSGY084）

Research progress of the protective effect and mechanism of C-phycocyanin on liver injury

LYU Kangning1, 2, WANG Lei2, QIN Song2, WANG Li3△   

  1. 1 School of Ocean, Yantai University, Yantai 264003, China; 2 Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences; 3 Yantai Qishan Hospital
  • Received:2021-11-24 Revised:2022-01-19 Published:2022-06-15 Online:2023-12-20

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摘要： 摘要：C-藻蓝蛋白（C-PC）是一种来自海洋藻类的含色素蛋白质，在多种炎性疾病和肿瘤治疗中表现出良好的效果。其对药物或毒性物质引起的肝损害、非酒精性脂肪性肝病、肝纤维化和肝脏缺血再灌注损伤等多种肝病具有保护作用。C-PC对肝损伤的保护作用主要是通过调节核因子（NF）-κB、磷脂酰肌醇3激酶/蛋白激酶B（PI3K/Akt）和AMP依赖的蛋白激酶（AMPK）等信号通路及抑制氧化应激等机制实现的，且对正常细胞没有毒性。因此，C-PC作为一种潜在的天然保肝海洋活性物质具有广阔的应用前景。就近年来C-PC对肝脏损伤的保护作用及机制的研究进展进行综述。

关键词: 蓝藻门, 肝疾病, 化学性与药物性肝损伤, 再灌注损伤, 肝肿瘤, 非酒精性脂肪性肝病, C-藻蓝蛋白

Abstract: Abstract: C-phycocyanin (C-PC) is a pigmented protein from marine algae, which demonstrates fair therapeutic effects on a variety of inflammatory diseases and tumors. It also shows protective effects on various kinds of liver diseases, such as liver damage caused by drugs or toxic substances, non-alcoholic fatty liver disease, liver fibrosis and liver ischemia-reperfusion injury. These beneficial effects on liver injury are mainly achieved by regulating the signal pathways of nuclear factor-κB (NF-κB), phosphatidylinositol 3 kinase / protein kinase B (PI3K/Akt) and adenosine monophosphate (AMP)-activated protein kinase (AMPK) and inhibiting oxidative stress. C-PC exhibits no toxicity to normal cells. Therefore, as a potential marine active substance for liver protection, C-PC has a broad application prospect. In this paper, the research progresses of the protective effect and mechanism of C-PC on different kinds of liver injury in recent years.

Key words: CYANOPHYTA, liver diseases, chemical and drug induced liver injury, reperfusion injury, liver neoplasms, non-alcoholic fatty liver disease, C-phycocyanin