乳酸杆菌在急性心肌梗死防治中的潜在机制及应用进展

doi:10.11958/20231153

摘要/Abstract

摘要：

随着临床、基础医学和代谢组学的发展，肠道菌群已成为研究热点并用于部分肠道疾病的诊疗。乳酸杆菌可产生并调控多种肠道代谢产物，参与脂质代谢、血栓形成、炎症及氧化应激，甚至铁死亡等，可能对心血管疾病的发生发展产生影响。就乳酸杆菌调控代谢、参与心肌梗死的病理生理机制及其在急性心肌梗死（AMI）中的临床应用进行综述，以期为AMI的预防和治疗提供新的参考。

关键词: 乳杆菌属, 急性心肌梗死, 胃肠道微生物组, 代谢产物, 临床转化

Abstract:

With the development of clinical, basic medicine and metabolomics, intestinal flora has gradually become a focus of research and has been used in the diagnosis and treatment of several intestinal diseases. Lactobacillus can produce and regulate a variety of intestinal metabolites, and participate in lipid metabolism, thrombosis, inflammation and oxidative stress, and even ferroptosis, which may have an impact on the occurrence and development of cardiovascular diseases. This article reviews the role of lactobacillus in the regulation of metabolism, involvement in the pathophysiological mechanism of myocardial infarction and its clinical application in acute myocardial infarction, providing a new reference for the prevention and treatment of AMI.

Key words: lactobacillus, acute myocardial infarction, gastrointestinal microbiome, metabolite, clinical transformation

中图分类号:

R542.22

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